-
Comparison between men and women of volume regulating hormones and aquaporin-2 excretion following graded central hypovolemia [Elektronski vir]Goswami, Nandu ...Central hypovolemia induced by orthostatic loading causes reno-vascular changes that can lead to orthostatic intolerance. In this study, we investigated volume regulating hormonal responses and ... reno-vascular changes in male and female subjects as they underwent central hypovolemia, induced by graded lower body negative pressure (LBNP). Aquaporin-2 (AQP2) excretion was measured as a biomarker for the renal system response to vasopressin. 37 young healthy subjects (n = 19 males; n=18 females) were subjected to graded LBNP until -40 mmHg LBNP. Under resting conditions, males had significantly higher copeptin (a stable peptide derived from vasopressin) levels compared with females. Adrenocorticotropin (ACTH), adrenomedullin (ADM), vasopressin (AVP) and brain natriuretic peptide (BNP) were not affected by our experimental protocol. Nevertheless, an analysis of ADM and BNP with the data normalized as percentages of the baseline value data showed an increase from baseline to 10 min after recovery in the males in ADM and in the females in BNP. Analysis of BNP and ADM raises the possibility of a preferential adaptive vascular response to central hypovolemia in males as shown by the normalized increase in ADM, whereas females showed a preferential renal response as shown by the normalized increase in BNP. Furthermore, our results suggest that there might be a difference between men and women in the copeptin response to alterations in orthostatic loading, simulated either using LBNP or during posture changes.Source: European journal of applied physiology [Elektronski vir]. - ISSN 1439-6327 (Vol. 119, no. 3, 2019, str. 633-643)Type of material - e-articlePublish date - 2019Language - englishCOBISS.SI-ID - 2048952330
Author
Goswami, Nandu |
Reichmuth, Johannes |
Di Mise, Annarita |
Brix, Bianca |
Roessler, Andreas |
Centrone, Mariangela |
Ranieri, Marianna |
Russo, Annamaria |
De Santo, Natale Gaspare |
Tamma, Grazia |
Sasso, Ferdinando Carlo |
Valenti, Giovanna, fiziologinja
Topics
adrenomedullin |
aquaporins |
copeptin |
lower body negative pressure |
orthostatic loading |
vasopressin
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Goswami, Nandu | 51771 |
Reichmuth, Johannes | ![]() |
Di Mise, Annarita | ![]() |
Brix, Bianca | ![]() |
Roessler, Andreas | ![]() |
Centrone, Mariangela | ![]() |
Ranieri, Marianna | ![]() |
Russo, Annamaria | ![]() |
De Santo, Natale Gaspare | ![]() |
Tamma, Grazia | ![]() |
Sasso, Ferdinando Carlo | ![]() |
Valenti, Giovanna, fiziologinja | ![]() |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.