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Vpliv proteinskega ekstrakta polimorfonuklearnih levkocitov na pobeg bakterije Shigella flexneri iz fagocitne vakuole : diplomska naloga = Effect of the protein extract from polymorphonuclear leukocytes on escape of Shigella flexneri from phagocytic vacuole : graduation thesisDraškovič, IrenaShigella flexneri se razmnožuje v epiteliskih celicah debelega črevesa in povzroča krvavo diyenterijo ali Ǵigeloyo. Bakterija vstopi v gostiteljsko celico y inducirano fagocitoyo in nato v manj kot ... petih minutah liyira fagocitno vakuolo, da pride v citoplaymo, kjer se raymnoÍuje in premika s pomočjo F-aktina gostiteljske celice. S. flexneri uspeǴno liyira fagocitno vakuolo v epitelijskih celicah in v makrofagih, ne more pa pobegniti iy fagocitne vakuole v polimorfonuklearnih levkocitih (PMN). Ni znano, kaj v PMN prepreři pobeg iy fagocitne vakuole. V diplomski nalogi smo želeli preveriti, ře proteini iy PMN vplivajo na invayivne sposobnosti S. flexneri in s tem prepreřijo pobeg iy fagocitne vakuole. Pokayali smo, da S. flexneri po tretiranju s proteinskim ekstraktom PMN Ǵe eno uro po indukciji fagocitoye ni sposobna tvoriti aktinskih repov, medtem ko 12% kontrolnih bakterij ima rep. Po treh urah infekcije si bakterije opomorejo in enako uřinkovito tvorijo aktinske repe kot kontrola. Poleg upořasnjene kinetike vstopa se pri 13% virulentnih bakterijah pojavijo aktinski obroři. Ne gre za neke nove strukture, ker so aktinski obroři prisotni tudi pri normalnem vstopu v celico,vendar v veliko manjǴi meri. Aktinski obroři so neodvisni od IcsA proteina, ki je do sedaj edini ynan protein ya veyavo F-aktina. Reyultati elektronske mikroskopije mořno podpirajo hipoteyo, da aktinski obroři predsavljajo akumuliran aktin na mestu vstopa bakterije v gostiteljsko celico.Trertiranje s poteinskim ekstraktom PMN torej upořasni vstop Íe v prvi fayi - pri indukciji fagocitoye, ře pa vpliva tudi na pobeg iy fagocitne vakuole, ne moremo reři. Aktivna komponenta proteinskega ekstrakta PMN, ki povyroři nastanek aktinskih obrořev, je najverjetneje bakteriostatiřni protein, ki poveřuje permeabilnost (BPI). BPI verjetno deluje na tip III sekrecijski aparat S. flexneri in zmanjša iylořanje invayijskih Ipa proteinov.Type of material - undergraduate thesis ; adult, seriousPublication and manufacture - Ljubljana : [I. Draškovič] : [BF, Enota medoddelčnega študija mikrobiologije], 1998Language - slovenianCOBISS.SI-ID - 2118776
Author
Draškovič, Irena
Other authors
Mahne, Ivan |
Mandić-Mulec, Ines
Topics
mikroorganizmi |
imunologija |
shigella flexneri |
polimorfonuklearni levkociti |
fagocitne vakuole |
fagocitne vakuole |
microorganisms |
immunology |
Shigella flexneri |
polymorphonuclear leukocites |
phagocyitic vacuoles |
phagocyitic vacuoles
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Library/institution |
City | Acronym | For loan | Other holdings |
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BF, Department of Food Science and Technology, Lj. | Ljubljana | BFZIV |
outside loan 3 cop.
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National Institute of Biology and BF, Department of Biology, Ljubljana | Ljubljana | BFBNIB |
reading room 1 cop.
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Mahne, Ivan | 07043 |
Mandić-Mulec, Ines | 05993 |
Source: Personal bibliographies
and: SICRIS
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