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New inhibitors of fungal 17ß-hydroxysteroid dehydrogenase based on the (1,5)-benzodiazepine scaffoldŽivec, Matej, 1979- ...The synthesis and activity of a new series of non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase are based on a 1,5-benzodiazepine scaffoldare presented. Their inhibitory potential was ... screened against 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus luuatus (17beta-HSDcI), a model enzyme of the short-chain dehydrogenasež reductase superfamily. Some of these compounds are potent inhibitors of 17beta-HSDcI activity, with IC50 values in the low micromolar range and represent promisinglead compounds that should be further developed and investigated as inhibitors of human 17beta-HSD isoforms, which are the enzymes associated withthe development of many hormone-dependent and neuronal diseases.Source: Journal of enzyme inhibition and medicinal chemistry. - ISSN 1475-6366 (vol. 22, no. 1, 2007, str. 29-36)Type of material - article, component partPublish date - 2007Language - englishCOBISS.SI-ID - 21592281
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source: Journal of enzyme inhibition and medicinal chemistry. - ISSN 1475-6366 (vol. 22, no. 1, 2007, str. 29-36)
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Year | Impact factor | Edition | Category | Classification | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Živec, Matej, 1979- | 26493 |
Sova, Matej, 1979- | 25490 |
Brunskole Švegelj, Mojca | 28343 |
Lenaršič, Roman | 16372 |
Lanišnik-Rižner, Tea | 11699 |
Gobec, Stanislav, 1970- | 15284 |
Source: Personal bibliographies
and: SICRIS
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