-
Bolus versus continuous low dose of Enalaprilat in congestive heart failure with acute refractory decompensationPodbregar, Matej ...The first dose of angiotensin-converting enzyme (ACE) inhibitors may trigger a considerable fall of blood pressure in chronic heart failure. The response may be dose-related. To determine hemodynamic ... and systemic oxygenation effectsof low dose enalaprilat we administred intravenous enalaprilat (0,004 mg/kg) as bolus (group B) or continuous 1-hour infusion (group C) in 20 patients with congestive heart failure due to ischemic heart disease with acute decompensation refractory to inotropic, vasodilator and diuretic therapy. Hemodynamic and systemic oxygenation variables were recorded at baseline (+0 min), +30, +60, +120, +180, and +360 min after the start of intervention. Mean arterial pressure (MAP) (p < 0.001), mean pulmonary artery pressure (MPAP) (p < 0.001), pulmonary artery occlusion pressure (PAOP) (p < 0.001), oxygen extraction ratio (ER) (p < 0.026) decreased regardless of enalaprilat application. Compared to group B, there was in group C prolonged decrease of MAP, MPAP, PAOP, ER and increase of pulmonary artery oxyhemoglobin saturation in regard to baseline values. Cardiac index, heart rate, central venous pressure and oxygen consumption index did not change. A low dose of intravenous enalaprilat (0.004 mg/kg) can be used to safely improve hemodynamics and systemic oxygenation in congestive heart failure due to ischemic heart disease with acute refractory decompensation.Source: Cardiology. - ISSN 0008-6312 (Letn. 91, št. 1, 1999, str. 41-49)Type of material - article, component part ; adult, seriousPublish date - 1999Language - englishCOBISS.SI-ID - 21667
Author
Podbregar, Matej |
Voga, Gorazd |
Horvat, Matija, 1935-2014 |
Žuran, Ivan |
Krivec, Bojan |
Skale, Rafael |
Parežnik, Roman
Topics
Heart diseases |
Therapy |
Heart failure, congestive |
Therapy |
Myocardial ischemia |
Therapy |
Enalaprilat |
Therapeutic use |
Angiotensin-converting enzyme inhibitors |
Therapeutic use |
Hemodynamics |
Srce, bolezni |
Zdravljenje |
Srčna odpoved, kongestivna |
Zdravljenje |
Miokardna ishemija |
Zdravljenje |
Enalaprilat |
Uporaba za zdravljenje |
Hemodinamika
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Podbregar, Matej | 21806 |
Voga, Gorazd | 14132 |
Horvat, Matija, 1935-2014 | 01531 |
Žuran, Ivan | 20739 |
Krivec, Bojan | 20732 |
Skale, Rafael | 21803 |
Parežnik, Roman | 20735 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.