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Predictive value and clinical utility of centrally assessed ER, PgR, and Ki-67 to select adjuvant endocrine therapy for premenopausal women with hormone receptor-positive, HER2-negative early breast cancer : TEXT and SOFT trialsRegan, Meredith M.The SOFT and TEXT randomized phase III trials investigated adjuvant endocrine therapies for premenopausal women with hormone receptor-positive (HR+) early breast cancer. We investigated the ... prognostic and predictive value of centrally assessed levels of estrogen receptor (ER), progesterone receptor (PgR), and Ki-67 expression in women with HER2-negative disease. Of 5707 women enrolled, 4115 with HER2-negative (HR+/HER2%) disease had ER, PgR, and Ki-67 centrally assessed by immunohistochemistry. Breast cancer-free interval (BCFI) was defined from randomization to first invasive local, regional, or distant recurrence or contralateral breast cancer. The prognostic and predictive values of ER, PgR and Ki-67 expression levels were assessed using Cox modeling and STEPP methodology. In this HR+/HER2- population, the median ER, PgR, and Ki-67 expressions were 95, 90, and 18 % immunostained cells. As most patients had strongly ER-positive tumors, the predictive value of ER levels could not be investigated. Lower PgR and higher Ki-67 expression were associated with reduced BCFI. There was no consistent evidence of heterogeneity of the relative treatment effects according to PgR or Ki-67 expression levels, though there was a greater 5-year absolute benefit of exemestane + ovarian function suppression (OFS) versus tamoxifen with or without OFS at lower levels of PgR and higher levels of Ki-67. Women with poor prognostic features of low PgR and/or high Ki-67 have greater absolute benefit from exemestane + OFS versus tamoxifen + OFS or tamoxifen alone, but individually PgR and Ki-67 are of limited predictive value for selecting adjuvant endocrine therapy for premenopausal women with HR+/HER2% early breast cancer.Source: Breast cancer research and treatment. - ISSN 0167-6806 (Vol. 154, iss. 2, 2015, str. 275-286)Type of material - article, component partPublish date - 2015Language - englishCOBISS.SI-ID - 2214011
Author
Regan, Meredith M.
Other authors
Škof, Erik
Topics
rak dojke |
hormonsko odvisen rak |
adjuvantno zdravljenje |
zgodnji rak dojke |
breast cancer |
adjuvant endocrine therapy |
early breast cancer
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source: Breast cancer research and treatment. - ISSN 0167-6806 (Vol. 154, iss. 2, 2015, str. 275-286)
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Database name | Field | Year |
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Regan, Meredith M. | ![]() |
Škof, Erik | 24572 |
Source: Personal bibliographies
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