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Pojav drugih primarnih rakov pri bolnikih z rakom grla v Sloveniji v obdobju 1961-1996 primer območne karcinogeneze : magistrsko deloEćimović, PatricijaBackground: The survival of patients with laryngeal cancer in Slovenia is poorer than in most European countries. One of the reasons could be high incidence of second primary cancers (SPC) in this ... population. Our aim was to ascertain incidence, time and site pattern of occurrence of SPC in patients with laryngeal cancer in Slovenia. Material and MethodsČ We conducted a retrospective cohort trial, which included 2435 patients with laryngeal cancer, registered at Cancer Registry of Slovenia in the period from 1961 to 1996. We excluded the patients in whom laryngeal cancer was established at autopsy or from death certificate or was a second primary cancer. To determinethe SPC, we used criteria recommended by IARCžIACR. We included both synchronous and metachronous SPC. We used the person-years approach and expressed the occurrence of SPC as standardized incidence ratio (SIR). We performed a separate analysis of incidence of SPC by follow-up time and by subsite of primary cancer (glottis and other parts of larynx). ResultsČ The average period of follow-up in our cohort was 4.78 years (range 0 to 27.8 years). SPC developed in 390 patients (16.02%, total SIR=2.83), most commonly in the head and neck region (SIR=9.96 for men and 100.0 for women), lung (SIR=4.14 for men and 20.7 for women) and esophagus (SIR=4.65 for men), which points to the strong role of common risk factors of smoking and alcohol. Maleswere at higher risk of developing SPC than females. Patients with cancer in other parts of the larynx were at higher risk than patients with glottis cancer. SPC were diagnosed in significant excess up to 20 years after the diagnosis of laryngeal cancer. Patients with glottis cancer had higher risk for SPC of the bladder. Other than that, we found no major difference in time and site distribution of SPC after the patients with glottis cancer and the patients with cancer in other parts of the larynx were analyzed separately. (Abstract truncated at 2000 characters)Type of material - master's thesisPublication and manufacture - Ljubljana : [P. Ećimović], 2000Language - slovenianCOBISS.SI-ID - 2245908
Author
Ećimović, Patricija
Other authors
Pompe-Kirn, Vera
Topics
Laryngeal neoplasms |
Neoplasms, second primary |
Epidemiology |
Slovenia |
Larinks, novotvorbe |
Novotvorbe, druge primarne |
Epidemiologija |
Slovenija |
medicinska onkologija |
otorinolaringologija
Library/institution |
City | Acronym | For loan | Other holdings |
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Institute of Oncology Ljubljana | Ljubljana | OILJ |
outside loan 2 cop.
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MF, Central Medical Library, Ljubljana | Ljubljana | CMK |
outside loan 1 cop.
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Pompe-Kirn, Vera | 03279 |
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