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Relevance of Tc-99m DMSA scintigraphy in renal transplant parenchymal imaging
Budihna, Nataša, 1943- ...
Tc-99m DMSA renal scintigraphy was performed in 40 renal grafts. Cyclosporin Aand glucocorticoids were given to all patients as antirejection therapy, and 11 also were given azathioprine. The kidneys ...were transplanted 1 to 97 months before the investigation. Seventy percent of kidneys had diffusely altered distribution of Tc-99m DMSA, and 43 percent had focal clear-cut parenchymal defects. The frequency of parenchymal defects observed on the DMSA scans was higher in patients who suffered manifest acute rejection episodes (8/16 versus9/24 patients, borderline significance, P less th. 0.06), but had no relation to the living or cadaveric donor transplant or its function. A combination of peritubular edema and interstitial fibrosis is considered the most probable explanation of diffuse changes. The high frequency of clear-cut parenchymal defects most likely results from symptomatic or asymptomatic rejection episodes complicated by renal transplant infarcts.
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