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Novel potent and selective thrombin inhibitors based on a central 1,4-benzoxazin-3(4H)-one scaffoldIlaš, Janez ; Tomašič, Tihomir ; Kikelj, DanijelNovel thrombin inhibitors with the central 1,4-benzoxazine-3(4H)-one scaffold,benzamidine P1 arginine side chain mimetic and various P3 moieties are described. ... 3-(Benzyl(2-(4-carbamimidoylbenzyl)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazi n-7-yl)amino)-3-oxopropanoic acid (7b), the most potent compound in the series, exhibited a Ki of 2.6 nM in vitro for thrombin and high selectivity against trypsin and factor XaSource: Journal of medicinal chemistry. - ISSN 0022-2623 (Vol. 51, no. 9, 2008, str. 2863-2867)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 2286193
Author
Ilaš, Janez |
Tomašič, Tihomir |
Kikelj, Danijel
Topics
trombinski inhibitorji |
sinteza |
tripsin |
faktor Xa
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Ilaš, Janez | 24400 |
Tomašič, Tihomir | 28334 |
Kikelj, Danijel | 01463 |
Source: Personal bibliographies
and: SICRIS
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