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Merjenje cisteinske proteinaze katepsina S v tumorskih in kontrolnih tkivih bolnikov s pljučnim rakom : diplomska naloga = Measurement of cysteine proteinase cathepsin S in tumor and control tissues of lung cancer patients : graduation thesisŠenk, MarjanaKatepsini so liyosomske proteinaye, ki hidroliyirajo raygradnjo peptidne veyi.Njihova glavna naloga je raygradnja ya celico nepotrebnih proteinov. Regulirajo jih specifiřni proteinayni inhibitorji ... kot so cistatini, stefini inkininogeni. PoruǴeno ravnovesje med njimi in s tem nekontrolirano delovanje katepsinov vodi do Ǵtevilnih boleyni, med drugim do invayeje tumorskih celic in metastayiranja. Katepsin S ima kljuřno vlogo v imunskem odgovoru, saj sodeluje pri predstavitvi antigena na kompleksu MHC II. Pomembno vlogo ima tudi v pljuřih, kjer omogořa gibljivost cilij na povrǴini dihalnih poti. Ya kvantitativno dolořanje katepsina S v kliniřnih vyorcih smo rayvili test ELISAs dvojnimi protitelesi. Uporabili smo dve vrsti monoklonskih protiteles celiřnih linij 1E3 in 2B4, ki prepoynavata rayliřna epitopa na katepsinu S. Obe celiřni liniji smo namnoÍili do maksimalne gostote in protitelesa iyolirali y afinitetno kromatografijo na Protein A-Sepharosi. Protitelesa celiřne linije 2B4 smo konjugirali y encimom hrenovo peroksidayo, optimiyiralinjihovo redřitev in jih uporabili kot detekcijska protitelesa pri testu ELISA. Y rayvitim testom smo dolořili koncentracijo katepsina S v citosolih tumorskega pljuřnega tkiva, odgovarjajořega netumorskega okoliǴkega tkiva ter v beygavkah s tumorskimi celicami ali brey njih. Ugotovili smo, da je katepsin S v tumorskem tkivu le rahlo poviǴan glede na kontrolno tkivo, karne kaÍe na pomembno vlogo, ki bi jo ta encim imel pri malignih spremembah. Ynařilno niÍje vrednosti smo dolořili v beygavkah s tumorskimi celicami v primerjavi y beygavkami brey njih. YniÍane vrednosti katepsina S v beygavkah bolnikov y napredovanim pljuřnim rakom so lahko poveyane y manjǴim Ǵtevilom limfocitov in slabǴim imunskim odyivom.Type of material - undergraduate thesis ; adult, seriousPublication and manufacture - Ljubljana : [M. Šenk] ; BF, Enota medoddelčnega študija mikrobiologije, 1999Language - slovenianCOBISS.SI-ID - 2287480
Author
Šenk, Marjana
Other authors
Avšič-Županc, Tatjana |
Kos, Janko, 1959-
Topics
katepsin S |
monoklonska protitelesa |
ELISA |
pljučni rak |
pljučni rak |
cathepsin S |
monoclonal antibody |
ELISA |
lung cancer |
lung cancer
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Library/institution |
City | Acronym | For loan | Other holdings |
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BF, Department of Food Science and Technology, Lj. | Ljubljana | BFZIV |
outside loan 2 cop.
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Year | Impact factor | Edition | Category | Classification | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Avšič-Županc, Tatjana | 10331 |
Kos, Janko, 1959- | 04648 |
Source: Personal bibliographies
and: SICRIS
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