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Relation of ultrasound morphologic characteristics of central pulmonary artery thromboemboli to their ex vivo lysibilityPodbregar, Matej ...BACKGROUND: Ultrasound morphology of massive central pulmonary artery thromboemboli (TE) is an independent predictor of 30-day mortality. The aim ofthis study was to asses ex vivo lysibility of ... morphologically different TE. METHODS: Forty-five central pulmonary artery TE, collected at autopsies, were divided into hypoechoic (group A) and hyperechoic (group B) categories. TE were lysed with alteplase in a perfusing system simulating pulmonary circulation for 1 hour. RESULTS: The grey scale mean of thrombi in group B washigher compared with group A (64 +/- 7 vs. 38 +/- 7, respectively, P < .01). Spontaneous lysis in group A did not differ compared with group B (2.2% +/- 0.5% vs. 2.1% +/- 0.4%, P = .4). After incubation with alteplase, the weight of TE was reduced more in group A than in group B (16% +/- 2% vs. 11% +/- 2%, P < .001). The grey scale mean negatively correlated with the percentage of TE weight reduction (0.768) (P < .001). CONCLUSION: Ultrasound morphology of TE from central pulmonary arteries correlates significantly withex vivo lysibility. Hypoechoic TE are more susceptible to thrombolysis than hyperechoic TE.Source: Journal of the American Society of Echocardiography. - ISSN 0894-7317 (Letn. 20, št. 3, 2007, str. 276-280)Type of material - article, component partPublish date - 2007Language - englishCOBISS.SI-ID - 23066585
Author
Podbregar, Matej |
Gabršček, Lucija |
Pakiž, Maja |
Blinc, Aleš |
Šabovič, Mišo |
Kralj, Eduard
Topics
Aged |
Fibrinolytic Agents |
Administration & Dosage |
Image Interpretation, Computer-Assisted |
Methods |
Prognosis |
Pulmonary Artery |
Drug Effects |
Ultrasonography |
Pulmonary Embolism |
Drug Therapy |
Ultrasonography |
Thrombolytic Therapy |
Methods |
Treatment Outcome |
Ultrasonography |
Methods |
Fibrinolitiki |
Pljučna arterija |
Pljučna embolija |
Prognoza |
Slika, interpretacija z računalnikom |
Starostniki |
Trombolitično zdravljenje |
Ultrasonografija |
Zdravljenje, izid
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Podbregar, Matej | 21806 |
Gabršček, Lucija | 21805 |
Pakiž, Maja | 29647 |
Blinc, Aleš | 07630 |
Šabovič, Mišo | 08094 |
Kralj, Eduard | ![]() |
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