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  • CTSB (cathepsin B) [Elektronski vir]
    Jevnikar, Zala ; Kos, Janko, 1959-
    The gene for human cathepsin B is located on chromosome 8p22 and it comprises 12 exons. The transcript length is 1017 bps which are translated to 339 residues preproenzyme. Cathepsin B mRNA consists ... of several variants produced by alternative exon splicing. Most variations involve the 5'- and 3'-UTR. Cathepsin B mRNAs lacking exon 2 are predominant in human tumours. In addition, human breast and colon carcinomas and human melanoma contain a cathepsin B transcript that is also missing exon 3 encoding the signal peptideand 7 residues of the activation propeptide. Transcription is initiated from more than one promoter region. In addition to the promoter region upstream from exon 1, there could be promoters upstream from exons 3 and 4. Each promoter region could be regulated independently.
    Source: Atlas of genetics and cytogenetics in oncology and haematology. - ISSN 1768-3262 ([10] str.)
    Type of material - e-article ; adult, serious
    Publish date - 2008
    Language - english
    COBISS.SI-ID - 2330737

    Link(s):

    http://atlasgeneticsoncology.org/Genes/CTSBID40202ch8p23.html

    Prost dostop



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