Long-term antibody response to human papillomavirus vaccines : up to 12 years of follow-up in the finnish maternity cohort

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Long-term antibody response to human papillomavirus vaccines : up to 12 years of follow-up in the finnish maternity cohort

Artemchuk, Hanna ...

Background. Most cervical cancers are caused by vaccine-preventable infections with human papillomaviruses (HPV). The HPV prophylactic vaccines Gardasil and Cervarix have been widely used for >10 ... years and are reported to induce high antibody levels. A head-to-head comparison of the antibody responses induced by the 2 vaccines has been performed only up to 5 years.Methods.Among 3300 Finnish females aged 16-17 years who got 1 of the 2 HPV vaccines in phase 3 licensure trials, virtually all consented to registry-based long-term follow-up. Linkage with the Finnish Maternity Cohort found that they donated >2500 serum samples up to 12 years later. Sera of 337 (38.6%) Gardasil and 730 (30.3%) Cervarix vaccine recipients were retrieved from the Finnish Maternity Cohort biobank and type-specific anti-HPV antibody levels were determined using in-house multiplexed heparin-HPV pseudovirion Luminex assay.Results.Anti-HPV-16 and anti-HPV-18 antibody levels remained stable and above natural infection-related antibody levels for up to 12 years for most vaccine recipients. The median antibody levels were higher among Cervarix recipients 7-12 years post vaccination (P < .0001).Conclusions.The stability of vaccine-induced antibody levels is in accordance with the high long-term protection reported previously. The differences in antibody levels induced by the 2 vaccines imply that continued follow-up to identify possible break-through cases and estimation of the minimal protective levels of serum antibodies is a research priority.

Source: The Journal of infectious diseases. - ISSN 0022-1899 (Vol. 219, no. 4, Jan. 2019, str. 582-589)

Type of material - article, component part ; adult, serious

Publish date - 2019

Language - english

COBISS.SI-ID - 23562499

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https://watermark.silverchair.com/jiy545.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAr0wggK5BgkqhkiG9w0BBwagggKqMIICpgIBADCCAp8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM6d-rVHnIqFYvN7iBAgEQgIICcPm4Nmqw3yszGF3TFjhKNwkUKJn5XphoU7qFYvLXV-dotWMCrCDZXt43QDUJmucHWtR3KZh5OLq96iCtz0geNg0fa3GmvaiU1R1U7w_FarLvPXV1Mn7g3G35TZim38mH0y-0911yFvSJrVUwvvz0BxbwP5j6iIe_IlPl1PWnGuR9XWbCnHYP5ypFBjrmBbfN6Dah4M9Zr5CoxxVAxY-K7m7436v5Jn-BqK-enaMTzn4aFp6Nm3w_0fUBiXJGR9jdDn67BP3CbD_OfQN255OdP0h-6koGVjyiNmwnNwFWiSZlBU3nK0a-Mmoo2FH9nlogKpBB4HjhRLH159LASjCGRjV51rgeZNpuoHGbODWZUtPgJ6n3NyNTtXht_wSgm-N-IR77jucNZA1YK9NS3xkiOMxXK8p1uMJTp0JKMg4Vrg27FUwLN2TdEbGnXdx8GdJDT5uWcH2sinBBkaREuUCzafWYqOpPAdDPXqx6l3G1zm32P3kow8UR-RLkvFhkV4x3XOUWgdcY46UCrA-hgxBIvS2mB1g5BQQLa9vep73bw_3u7kh3jAmHxbTDXnFlQjjhuKVk2pjbOgSxu3MPJzYfIHiw644DH6K-IszK7RF6ZSaHQuc2y1YijlettsJjOjAXvOmxRFZMXrotulfPCy36SkVYxrnbGnTi4b-D3yTnGqKKsuT1aAjEIvkj4rf0UlYQ-Sx2Bz0eQ8JSpj6qGXjoM2Ug9PEL-upC3gT-5D-_0J2bEMeMMrpOjkteI-4fVCyrx_BGr9cfD1qbG495qsK67SmXVrH7PFYOLMvzy29e09z4SeRd-CNP36oWNIEu1NznHQ
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source: The Journal of infectious diseases. - ISSN 0022-1899 (Vol. 219, no. 4, Jan. 2019, str. 582-589)

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Artemchuk, Hanna
Eriksson, Tiina
Poljak, Mario, 1965-	11622
Surcel, Heljä-Marja
Dillner, J.
Lehtinen, Matti
Faust, Helena

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