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Adaptation of muscle fibre types and capillary network to acute denervation and shortlasting reinnervationČebašek, Vita ...We postulated that, in rat extensor digitorum longus muscle (EDL), the length of capillaries per fibre surface area (Lcap/Sfib) and per fibre volume (Lcap/Vfib) could reflect fibre-type ... transformations accompanied by changes inoxidative metabolic profile and selective fibre-type atrophy. We excised ratEDL muscle 2 weeks after the sciatic nerve was cut (acute denervation; DEDL) and 4 weeks after the nerve was crushed (early reinnervation; REDL) and characterised muscle fibre-type transformation by the expression of myosin heavy-chain isoforms and by succinate dehydrogenase (SDH) and nicotinoamide adenine dinucleotide-tetrazolium reductase (NADH-TR) reactions. The numericalpercentage (N/N) and area percentage (A/A) of pure and hybrid fibres and their diameter were determined, as was the A/A of SDH- and NADH-TR-positive fibres. The length of capillaries per fibre length (Lcap/Lfib), Lcap/Sfib and Lcap/Vfib were estimated in REDL and Lcap/Vfib in DEDL. In DEDL, the type 2x and 2b fibres evidently atrophied, with the N/N oftype 2x fibres being lower and that of hybrid fibres higher. In REDL, the N/N of hybrid fibres was even higher, consequent to a lower N/N of type 2b fibres; however, fibre diameters approached values of the control EDL. Compared with control EDL, denervated and reinnervated muscles exhibited a higher A/A of oxidative fibres. This is probably the result of fibre-type transformation and selective fibre atrophy. We conclude that capillary length does not change during acute denervation and early reinnervation. The obtainedhigher values of Lcap/Sfib and Lcap/Vfib are related to changes in muscle fibre cross-sectional area.Source: Cell and tissue research. - ISSN 0302-766X (Letn. 330, št. 2, 2007, str. 279-289)Type of material - article, component partPublish date - 2007Language - englishCOBISS.SI-ID - 23624921
Author
Čebašek, Vita |
Kubínová, Lucie |
Janáček, Jiří |
Ribarič, Samo |
Eržen, Ida
Topics
Muscle Denervation |
Muscle, Skeletal |
Blood Supply |
Capillaries |
Anatomy And Histology |
Sciatic Nerve |
Injuries |
Muscle Fibers |
Nerve Crush |
Nerve Regeneration |
Myosin Heavy Chains |
Succinate Dehydrogenase |
Nad |
Tetrazolium Salts |
Rats, Wistar |
Ishiadični živec |
Kapilare |
Mišica skeletna |
Mišica, denervacija |
Mišična vlakna |
Miozin težkih verig |
NAD |
Podgane, Wistar |
Sukcinatna dehidrogenaza |
Tetrazolijeve soli |
Živec stisnjen |
Živec, regeneracija
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Database name | Field | Year |
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Čebašek, Vita | 11785 |
Kubínová, Lucie | ![]() |
Janáček, Jiří | ![]() |
Ribarič, Samo | 08010 |
Eržen, Ida | 05329 |
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