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Standard citrate versus sequential citrate/anticoagulant-free anticoagulation during hemodyalisis : a randomized trialButurović-Ponikvar, Jadranka ...In a randomized study, sequential anticoagulation for hemodialysis (citrate for the first 3.5 h, switching to 30-min anticoagulation-free hemodialysis) was compared to standard citrate ... anticoagulation. Fifty-two hemodialysis procedures were randomized either to sequential (n = 27) or standard citrate group (n = 25). The antithrombotic effect in the circuit was visually assessedafter hemodialysis using a score from 1 (total clotting) to 5 (no clotting). The antitbrombotic score for sequential versus standard group was as follows: dialyzer, 4.0 +- 1.1 versus 4.8 +- 0.4 (P < 0.07 ); arterial bubble trap, 4.0 +- 1.2 versus 4.7 +- 0.6 (P = 0.013); venous bubble trap, 4.0+- 1.3 versus 4.8 +- 0.6 (P < 0.01). Serum citrate levels during sequentialversus standard citrate anticoagulation (`mol/L) were as follows: atthe beginning, 143+- 65 versus 148 +- 77 (not significant (NSđ); after 2 h, 317 `- 157 versus 354 +- 111 (NS); at the end, 125 +- 81 versus 405 +- 133 (P < 0.01). Sequential anticoagulation reduces the final serum citrate concentration to predialysis level. It can be a good anticoagulation strategy for patients in whom the reduction of citrate load is desired. Key Words: Anticoagulation-Citrate-Hemodialysis-Metabolic alkalosis-Regional citrate anticoagulation-Serum citrate levels.Source: Artificial organs. - ISSN 0160-564X (Letn. 32, št. 1, 2008, str. 77-81)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 23651289
Author
Buturović-Ponikvar, Jadranka |
Gubenšek, Jakob |
Černe, Darko |
Ponikvar, Rafael
Topics
Hemodialysis |
Hemodialysis Solutions |
Citrates |
Anticoagulants |
Alkalosis |
Randomized Controlled Trials |
Alkaloza |
Antikoagulansi |
Citrati |
Hemodializne raztopine |
Naključno kontrolirane, klinične preiskave
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Buturović-Ponikvar, Jadranka | 10649 |
Gubenšek, Jakob | 24053 |
Černe, Darko | 15099 |
Ponikvar, Rafael | 01987 |
Source: Personal bibliographies
and: SICRIS
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