-
Interaction between hormonal receptor status, age and survival in patients with BRCA1/2 germline mutations [Elektronski vir] : a systematic review and meta-regressionTempleton, Arnoud J. ...Germline mutations in the BRCA1 and BRCA2 genes are the most frequent known hereditary causes of familial breast cancer. Little is known about the interaction of age at diagnosis, estrogen receptor ... (ER) and progesterone receptor (PgR) expression and outcomes in patients with BRCA1 or BRCA2 mutations. METHODS: A PubMed search identified publications exploring the association between BRCA mutations and clinical outcome. Hazard ratios (HR) for overall survival were extracted from multivariable analyses. Hazard ratios were weighted and pooled using generic inverse-variance and random-effect modeling. Meta-regression weighted by total study sample size was conducted to explore the influence of age, ER and PgR expression on the association between BRCA mutations and overall survival. RESULTS: A total of 16 studies comprising 10,180 patients were included in the analyses. BRCA mutations were not associated with worse overall survival (HR 1.06, 95% CI 0.84-1.34, p = 0.61). A similar finding was observed when evaluating the influence of BRCA1 and BRCA2 mutations on overall survival independently (BRCA1: HR 1.20, 95% CI 0.89-1.61, p = 0.24; BRCA2: HR 1.01, 95% CI 0.80-1.27, p = 0.95). Meta-regression identified an inverse association between ER expression and overall survival (% = -0.75, p = 0.02) in BRCA1 mutation carriers but no association with age or PgR expression (% = -0.45, p = 0.23 and % = 0.02, p = 0.97, respectively). No association was found for BRCA2 mutation status and age, ER, or PgR expression. CONCLUSION: ER-expression appears to be an effect modifier in patients with BRCA1 mutations, but not among those with BRCA2 mutations.Source: PloS one [Elektronski vir]. - ISSN 1932-6203 (Vol. 11, no. 5, May 2016)Type of material - e-articlePublish date - 2016Language - englishCOBISS.SI-ID - 2390651
Author
Templeton, Arnoud J. |
Díez-González, Laura |
Vera-Badillo, Francisco Emilio |
Tibau Martorell, Ariadna |
Goldstein, Robyn |
Šeruga, Boštjan, 1973- |
Srikanthan, Amirrtha |
Pandiella, Atanasio |
Amir, Eitan |
Ocaña, Alberto
Topics
rak dojke |
dedni rak |
BRCA |
mutacije |
breast cancer |
BRCA mutations |
familial breast cancer
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Templeton, Arnoud J. | ![]() |
Díez-González, Laura | ![]() |
Vera-Badillo, Francisco Emilio | ![]() |
Tibau Martorell, Ariadna | ![]() |
Goldstein, Robyn | ![]() |
Šeruga, Boštjan, 1973- | 24577 |
Srikanthan, Amirrtha | ![]() |
Pandiella, Atanasio | ![]() |
Amir, Eitan | ![]() |
Ocaña, Alberto | ![]() |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.