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Prevalence and clinical associations of anti-KU antibodies in patients with systemic sclerosis : a European EUSTAR - initiated multicentre case-control studyRozman, Blaž, 1944- ...Objectives: To determine the prevalence of anti-Ku antibodies in 625 patients with systemic sclerosis (SSc) from six European rheumatologic centres and to evaluate their clinical and serologic ... characteristics. Methods: Sera of 625 consecutive patients with either limited cutaneous or diffuse cutaneous SSc were tested for antibodies to Ku antigen together with other extractable nuclear antigens by counter-immunoelectrophoresis. A case-control design with calculation of Bootstrap 95% confidence intervals derived from anti-Ku negative control patients was used to evaluate clinical associations of anti-Ku antibodies. Sera of anti-Ku positive SSc patients and control group were additionally tested by immunofluorescence on Hep-2 cell substrates and line immunoassay. Results: Anti-Ku antibodies were found in sera of 14/625 (2.2%) SSc patients. Ten out of fourteen anti-Ku positive SSc patients had no other anti-ENA antibodies detected by counterimmuno-electrophoresis. Using the case control design, anti-Ku antibodies were significantly associated withmusculoskeletal manifestations such as clinical markers of myositis, arthritis, and joint contractures. In addition, a significant negative correlation of anti-Ku antibodies was found with vascular manifestation such as fingertip ulcers and teleangiectasias. There was a striking absence of anti-centromere antibodies as well as anti-PM/Scl antibodies in anti-Ku positive patients. As expected, anti-Scl-70 and punctate nucleolar immunofluorescence pattern were present only in single cases. Conclusion: Thisis the largest cohort to date focusing on the prevalence of anti-Ku antibodies in SSc patients. The case control approach was able to demonstrate a clinically distinct subset of anti-Ku positive SSc patients with only relative clinical differences in skeletal features. However, the notable exceptions were signs of myositis. (Abstract truncated at 2000 characters)Source: Annals of the Rheumatic Diseases. - ISSN 0003-4967 (Letn. 67, št. 9, 2008, str. 1282-1286)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 24001497
Author
Rozman, Blaž, 1944- |
Čučnik, Saša |
Sodin-Šemrl, Snežna, 1962- |
Czirjak, L |
Varju, C |
Kveder, Tanja
Topics
Scleroderma, Systemic |
Immunology |
Diagnosis |
Autoantibodies |
Autoantigens |
Counterimmunoelectrophoresis |
Case-Control Studies |
Multicenter Studies |
Sklerodermija sistemska |
Protitočna imunoelekroforeza |
Avtoantigeni |
Avtoprotitelesa |
Kontrolirane študije |
Policentrične študije
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Database name | Field | Year |
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Rozman, Blaž, 1944- | 07180 |
Čučnik, Saša | 16362 |
Sodin-Šemrl, Snežna, 1962- | 26481 |
Czirjak, L | ![]() |
Varju, C | ![]() |
Kveder, Tanja | 02066 |
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