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Continuous axial-flow left ventricular assist device (Jarvik 2000) maintains kidney and liver perfusion for up to 6 monthsLetsou, George V. ...Background: The Jarvik 2000 axial flow left ventricular assist device (LVAD), under development for the past decade, has the potential to support patients temporarily until cardiac transplantation or ... as a permanent circulatory support, without the size limitations of other implantable systems. Methods: To assess its ability to perfuse the kidneys and liver, we monitored renal andhepatic function in 10 patients who received the Jarvik 2000 LVAD as a bridge to transplantation. Left ventricular assistance was maintained for up to 214 days (> 6 months), and renal and hepatic function were monitored at least weekly. Results: Renal function before LVAD implantation in these patients was normal in 7 (creatinine, < 1.5) and moderately impaired in 3 (creatinine, 1.2 to 2.0). Hepatic function was normal in 7 patients before LVAD implantation (total bilirubin< 1.2; serum glutamic-oxaloacetic transaminase (SGOT), < 40; serum glutamic-pyruvic transaminase (SGPT), < 50) and normal at the time of transplantation in all 10 patients. Of the 3 patients with abnormal hepatic function before LVAD implantation, 1 patient had also had moderate renal dysfunction. CONCLUSIONS: Despite reduced pulsatility, the Jarvik 2000 LVAD improves or maintains excellent renal and hepatic function during periods of circulatory assistance in patients awaitingtransplantation.Source: The Annals of thoracic surgery. - ISSN 0003-4975 (Letn. 76, št. 4, 2003, str. 1167-1170)Type of material - article, component partPublish date - 2003Language - englishCOBISS.SI-ID - 24111577
Author
Letsou, George V. |
Myers, Timothy J. |
Gregorič, Igor |
Delgado, Reynolds |
Shah, Nyma A. |
Robertson, Kimberly D. |
Radovančević, Branislav |
Frazier, O.H.
Topics
Heart-Assist Devices |
Adult |
Aged |
Bilirubin |
Blood |
Creatinine |
Blood |
Kidney |
Blood Supply |
Physiology |
Liver |
Blood Supply |
Physiology |
Prosthesis Design |
Time Factors |
Srce-podporne naprave |
Kreatinin |
Ledvica |
Jetra |
Starostniki |
Odrasli |
Bilirubin |
Časovni faktorji
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Letsou, George V. | ![]() |
Myers, Timothy J. | ![]() |
Gregorič, Igor | 29980 |
Delgado, Reynolds | ![]() |
Shah, Nyma A. | ![]() |
Robertson, Kimberly D. | ![]() |
Radovančević, Branislav | ![]() |
Frazier, O.H. | ![]() |
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