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Compartmentalization of calcium entry pathways in mouse rodsKrižaj, DavidPhotoreceptor metabolism, gene expression and synaptic transmission take placein a highly polarized structure consisting of the ellipsoid, subellipsoid, cell body and synaptic terminal regions. ... Although calcium, a keysecond messenger, regulates cellular functions throughout the photoreceptor, the molecular mechanisms underlying local region-specific action of Ca2+ in photoreceptors are poorly understood. I have investigated the compartmentalization of voltage-dependent and independent Ca2+ channels inmouse photoreceptors. Transient receptor potential channels isoform 6 (TRPC6), a putative store-operated Ca2+ channel, was selectively localized to the cell body of rods. By contrast, voltage-operated Ca2+ channels were expressed in the synaptic terminal and in the ellipsoid/subellipsoid regions. Likewise, Ca2+ store transporters and channels were strongly associated with the subellipsoid region. A moderate TRPC6 signal was observed in cell bodies of bipolar, amacrine and ganglion cells, but was absent from both plexiform layers. These results suggest that Ca2+ entry mechanisms in mammalian photoreceptors and bipolar cells are highly compartmentalized, consistent withlocal, region-specific activation of Ca2+-dependent processes.Source: The European journal of neuroscience. - ISSN 0953-816X (Letn. 22, št. 12, 2005, str. 3292-3296)Type of material - article, component partPublish date - 2005Language - englishCOBISS.SI-ID - 24144345
Author
Križaj, David
Topics
Animals |
Blotting, Northern |
Methods |
Blotting, Western |
Methods |
Calcium |
Metabolism |
Calcium-Binding Protein, Vitamin D-Dependent |
Metabolism |
Fluorescent Antibody Technique |
Methods |
Glutamate Synthase |
Metabolism |
Mice |
Rna, Messenger |
Metabolism |
Rods (Retina) |
Cytology |
Metabolism |
Second Messenger Systems |
Physiology |
Fluorescentna tehnika za protitelesa |
RNA, prenašalna |
Drugi, sporočilni sistemi |
Živali |
Blot, Northern |
Miši |
Paličice (mrežnica) |
Kalcij |
Kalcij-vezalna beljakovina, vitamin D-odvisna |
Blot, Western |
Glutamatna sintaza
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Križaj, David | 07133 |
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