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  • Neurovascular coupling during ageing and in migraneurs = Živčnožilna sklopitev pri starejših in bolnikih z migreno
    Zaletel, Marjan, 1963-
    A noninvasive assessment of neurovascular coupling using visually evoked cerebral blood flow velocity responses (VEFR) and visual evoked potentials (VEP), during normal ageing and in migraneurs, ... would be of great importance for interpretation of functional neuroimaging methods. According to the recentfindings neurovascular coupling could be altered in older subjects and in migraneurs. The records were made from a group of healthy younger (37.5 9.4years; 20 subjects) and older subjects (69.5 5.9 years; 20 subjects) as well as from patients with migraine (36.6 10.4 years) interictally. The stimulus was a black-and-white checkerboard with visual contrasts of 1%, 10% and 100%. The VEFR were measured in the posterior cerebral artery using transcranial Doppler (TCD), and the VEP were recoded from occipital leads. To test the relationship between the VEFR, the VEP and the visual contrast, a linear regression analysis was performed. A significant increase of the VEFR and the VEP to graded visual contrasts (p < 0.01) was found both in the younger and older subjects. The linear regression showed a significant positive association between the VEP in the VEFR (r = 0.66, p < 0.01) of the younger and older subjects (r = 0.74, p < 0.01). The regression coefficient ofthe younger subjects was significantly higher (b = 0.54; SE = 0.07) than that of the older ones (b = 0.40; SE = 0.05) (p < 0.01). Also, we found an increase of VEFR and VEP within group of migraneurs (p < 0.01). VEFR were significantly higher in migraneurs (p < 0.01) compared to controls, while VEP did not significantly differ between the groups (p > 0.05). The regression showed a significant association between VEP and VEFR migraneurs (r = 0.63, p < 0.01). The regression coefficient of migraneurs (b = 0.88, SE = 0.08) was significantly higher than of healthy subjects (b = 0.55, SE = 0.07) (p = 0.04). (Abstract truncated at 2000 characters)
    Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 77, suppl. II, 2008, str. II-65-II-70)
    Type of material - article, component part
    Publish date - 2008
    Language - english
    COBISS.SI-ID - 24289753

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    Digitalna knjižnica Slovenije - dLib.si

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