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Prevalenca protiteles proti virusu hepatitisa E pri slovenskih bolnikih z velikim tveganjem parenteralno prenosljivih okužb : diplomska naloga = Prevalence of antibodies to hepatitis E virus among Slovenian patients with high risk of parenterally transmitted infections : graduation thesis
Šoba, Barbara
Virus hepatitisa E (HEV) se najpogosteje prenaǴa fekalno-oralno in je endemiřen v nekaterih delih Afrike, Azije in Latinske Amerike. OkuÍbe s HEV sov razvitih drÍavah redke in so veřinoma povezane s ...sporadiřnimi vnosi virusaiz endemskih podrořij. V zadnjem řasu se predvsem iz razvitih drÍav vse veř porořa o moÍnem parenteralnem nařinu prenosa HEV. Domneve o moÍnem parenteralnem prenosu HEV temeljijo predvsem na tem, da so v nekaterih raziskavah dokazali statistiřno pomembno viǴjo prevalenco okuÍbe s HEV v skupinah oseb z velikim tveganjem za parenteralno prenosljive okuÍbe v primerjavi s sploǴno populacijo oz. s krvodajalci. V diplomski nalogi smo ugotavljali prevalenco protiteles proti HEV pri slovenskih osebah z velikim tveganjem za parenteralno prenosljive okuÍbe. V raziskavo smo vkljuřili 252 serumskih vzorcev, odvzetih osebam z velikim tveganjem za parenteralno prenosljive okuÍbe, in sicer 39 hemofilikom, 102 hemodializnima bolnikoma ter 111 intravenskim uÍivalcem drog. Prisotnost protiteles smo ugotavljali z encimsko imunskimi testi. Anti-HEV IgG pozitivnih je bilo 7/252 (2,8%) oseb, od tega 2/39 (5,1%) hemofilika, 3/102 (2,9%) hemodializni bolniki in 2/111 (1,8%) intravenska uÍivalca drog. Nihře od sedmih anti-HEV IgG pozitivnih osebni bil anti-HEV IgM pozitiven. Na osnovi rezultatov naǴe raziskave in primerjave le-teh z rezultati podobnih raziskav, ki so bile izvedene drugod posvetu, ter s prevalenco protiteles proti HEV pri slovenskih krvodajalcih, lahko zakljuřimo, da moÍnosti parenteralnega nařina prenosa okuÍbe s HEV pri nekaterih bolnikih z velikim tveganjem za parenteralno prenosljive okuÍbe ne moremo izkljuřiti.
Type of material - undergraduate thesis
; adult, serious
Publication and manufacture - Ljubljana : [B. Šoba] ; [BF, Enota medoddelčnega študija mikrobiologije], 2000
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