-
Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients : a study of polymorphisms affecting methotrexate transport and folate metabolismBohanec Grabar, Petra ...Objective: Methotrexate (MTX) is a disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis (RA). Genetic polymorphisms of reduced folate carrier (RFC1 A80G), P-glycoprotein ... (MDR1 G2677T>A/C and C3435T), 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), thymidylate synthase (TS 2R-->3R), methionine synthase (MS A2756G) and methionine synthase reductase (MTRR A66G) modify MTX transport and metabolic effects and may influence the treatment response. METHODS: A genotyping approach was used to determine the studied polymorphisms in 213 RA patients. Results: We observed that 56 (26.3%) patients discontinued MTX treatment due to poor response and/or toxicity. RFC1 A80G and MDR1 C3435T polymorphisms increased the risk for overall MTX toxicity (P = 0.039, OR = 3.574, 95% CI = 1.065-11.993 and P = 0.032, OR = 7.801, 95% CI = 1.194-50.960 respectively), while MTHFR A1298C polymorphism had a protective effect on overall MTX toxicity (P = 0.027, OR = 0.170, 95% CI = 0.035-0.820). Conclusion: Our results suggest that genetic polymorphisms in the folate metabolic pathway andMTX transporters modify the toxicity but not the efficacy of MTX treatment.Source: European Journal of Clinical Pharmacology. - ISSN 0031-6970 (Letn. 64, št. 11, 2008, str. 1057-1068)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 24927193
Author
Bohanec Grabar, Petra |
Logar, Dušan, 1951- |
Lestan, Boris |
Dolžan, Vita
Topics
Arthritis, Rheumatoid |
Drug Therapy |
Genetics |
Methotrexate |
Toxicity |
Polymorphism (Genetics) |
P-Glycoprotein |
Folic Acid |
Metabolism |
Methyltransferases |
Genotype |
Artritis revmatični |
P-glikoprotein |
Polimorfizem (genetika) |
Metotreksat |
Folna kislina |
Metiltransferaze |
Genotip
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Bohanec Grabar, Petra | 25438 |
Logar, Dušan, 1951- | 10080 |
Lestan, Boris | 02087 |
Dolžan, Vita | 11711 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.