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Hepatitis C virus genotypes in 1,504 patients in Slovenia, 1993-2007Seme, Katja, 1966- ...In order to identify the main routes of hepatitis C (HCV) transmission and to determine the HCV genotype distribution and its dynamics during a 15-year period in Slovenia, HCV genotypes were detected ... using the INNO-LiPA HCV II (Innogenetics) test for serum samples obtained from 1,504 patients representing 72.6% of all patients with chronic hepatitis C diagnosed from 1993 to 2007. HCV genotype 1 was predominant (56%), followed by genotypes 3, 2, and 4, with a prevalence of 37.8%, 5%, and 1.2%, respectively. HCV genotypes 5 and 6 were not detected in any patient. Patients infected with HCVgenotype 3 were significantly younger (mean age 28.9 +/- 8.5 years) than those infected with genotype 1 (mean age 38.9 +/- 14.8 years; P < 0.0001) and those infected with HCV genotype 2 (mean age 50.3 +/- 18.2 years; P < 0.0001).Intravenous drug use was identified as the most frequent possible HCVtransmission route (34.3%), followed by medical-related transmission such as transfusion of HCV-contaminated blood or blood products, and hemodialysis (12.5%). Being an intravenous drug user was found to be strongly associated with HCV genotype 3 (OR, 3.71 š95% CI, 2.97-4.65đ; P < 0.0001) and reporting infection by transfusion of blood or blood products was found to be strongly associated with HCV genotype 1 (OR, 3.28 š95% CI, 2.18-4.95đ; P < 0.0001). During the 15-year period, the proportion of genotype 3 increased substantially, reflecting the fact that the HCV epidemic in Slovenia is driven mostly by intravenous drug use.Source: Journal of medical virology. - ISSN 0146-6615 (Letn. 81, št. 4, 2009, str. 634-639)Type of material - article, component partPublish date - 2009Language - englishCOBISS.SI-ID - 25417945
Author
Seme, Katja, 1966- |
Vrhovac, Maja |
Štamol, Tina |
Matičič, Mojca |
Lešničar, Gorazd |
Baklan, Zvonko |
Meglič-Volkar, Jelka |
Rajter, Mojca |
Štepec, Srečko |
Lunar, Maja M., 1982- |
Poljak, Mario, 1965-
Topics
Hepatitis C |
Transmission |
Hepatitis C-Like Viruses |
Genotype |
Hepatitis C Antibodies |
Rna, Viral |
Blood Donors |
Hemodialysis |
Substance Abuse, Intravenous |
Hepatitis, C-podobni virusi |
Genotip |
Hepatitis C, protitelesa |
RNA virusna |
Hepatitis C |
Krvodajalci |
Snovi, zloraba intravenska
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Seme, Katja, 1966- | 14504 |
Vrhovac, Maja | ![]() |
Štamol, Tina | 25988 |
Matičič, Mojca | 11348 |
Lešničar, Gorazd | 14096 |
Baklan, Zvonko | 20402 |
Meglič-Volkar, Jelka | 19774 |
Rajter, Mojca | 01408 |
Štepec, Srečko | 10067 |
Lunar, Maja M., 1982- | 54554 |
Poljak, Mario, 1965- | 11622 |
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