-
Laboratorijski vidiki venske tromboze : dejavniki tveganja, prepoznavanje in spremljanje zdravljenja = Laboratory aspects of venous thrombosis : risk factors, identification and therapy monitoring : doktorska disertacijaBožič, Mojca, 1970-Mildly elevated levels of plasma homocysteine (hyperhomocysteinemia) increase in general population the risk of deep-vein thrombosis (DVT) for about three-fold. We found on average for 10 % higher ... levels of total piasma homocysteine in patients with pregnancy related DVT than in healthy women. Plasma homocysteine was not associated with methylenetetrahydrofolate reductase polymorphism C677T. 1Vlechanisms, which lead to the atherogenic and thrombotic complications of hyperhomocysteinemia, are not well understood. However, homocysteine has a detrimental effect on endothelium. The aim of our study was to assess the influence of hyperhomocysteinemia on tissue plasminogen activator and tissue plasminogen activator inhibitor - two fibrinolytic proteins released by endothelium. Although a correlation between homocysteine and both fibrinolytic proteins was observed, no difference in .these two proteins was found in patients with DVT with or without hyperhomocysteinemia. High fibrinogen is also a risk factor for DVT. In the recent years several polymorphisms in fibrinogen genes were found, that could influence fibrinogen levels in plasma. We tried to assess the role of fibrinogen polymorphisms Taq I, Hae III and Bcl I on the development of DVT. We found similar frequencies of the polymorphisms in patients with DVT and healthy subjects. An association between polymorphisms and plasma fibrinogen was observed only in healthy subjects. The hypothesis of causal role of fibrinogen in DVT aetiology was rejected. Clinical signs of DVT are unspecifictherefore, in patients with suspected DVT expensive and time-consuming objective testing is needed. Low levels of D-dimer, a degradation product of cross-linked fibrin, can reliably exclude DVT. In our study, Ddimer rrieasured with ELISA method showed the best diagnostic accuracy(100 sensitivity and 78% specificity). (Abstract truncated at 2000 characters)Type of material - dissertationPublication and manufacture - Ljubljana : [M. Božič], 2003Language - slovenianCOBISS.SI-ID - 2583572
Author
Božič, Mojca, 1970-
Other authors
Stegnar, Mojca
Topics
Venous thrombosis |
Diagnosis |
Venous thrombosis |
Therapy |
Venous thrombosis |
Physiopatology |
Laboratory techniques and procedures |
Homocysteine |
Blood |
Fibrinogen |
Genetics |
Fibrinogen |
Blood |
Polymorphism (genetics) |
Venska tromboza |
Diagnostika |
Venska tromboza |
Terapija |
Venska tromboza |
Patofiziologija |
Laboratorijske tehnike in postopki |
Homocistein |
Kri |
Fibrinogen |
Genetika |
Fibrinogen |
Kri |
Polimorfizem (genetika) |
žilne bolezni
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Library/institution |
City | Acronym | For loan | Other holdings |
---|---|---|---|---|
MF, Central Medical Library, Ljubljana | Ljubljana | CMK |
outside loan 2 cop.
|
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Božič, Mojca, 1970- | 15637 |
Stegnar, Mojca | 05034 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.