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Poor fibrinolytic response to venous occlusion by different criteria in patients with deep vein thrombosisStegnar, Mojca ...Five criteria for poor response to a 20 min venous occlusion test were applied to 58 patients 3 months or more after acute deep vein thrombosis (DVT). The criteria were arbitrarily defined as the ... last 5 percentiles of response distributions in an age- and sex-matched healthy control group of 51 subjects. The criteria were: 1. euglobulin clot lysis time after venous occlusion greater than or equal to 140 min; 2. t-PA activity after venous occlusion less than or equal to 0.04 IU/ml; 3. increase in t-PA antigen above resting value less than or equal to 2-fold; 4. ratio between t-PA antigen increase and resting PAI activity less than or equal to 0.5 ng/IU; 5. PAI activity after venous occlusion greater than or equal to 6 IU/ml. The last criterion of poor response was the only one that was significantly more frequently reached by patients than by controls: 28 percent (p less than 0.005) of all DVT patients and 35 percent (p less than 0.005) of the subgroup with idiopathic DVT (N = 34) were found to be poor responders. The percentage of poor responders according to the other four criteria was 7-11 percent in all patients and 9-15 percent in the subgroup with idiopathic DVT and thus was not significantly higher than in controls (5 percent by definition). It was concluded that residual PAI activity after venous occlusion might be a useful criterion for prospective studies on recurrence of DVT.Source: Thrombosis research. - ISSN 0049-3848 (Letn. 64, št. 4, 1991, str. 445-453)Type of material - article, component partPublish date - 1991Language - englishCOBISS.SI-ID - 2590425
Author
Stegnar, Mojca |
Peternel, Polona |
Keber, Dušan, 1947- |
Vene, Nina
Topics
Fibrinolysis |
Thrombophlebitis |
Physiopathology |
Adolescence |
Adult |
Alteplase |
Analysis |
Blood glucose |
Analysis |
Body mass index |
Constriction |
Middle age |
Plasminogen inactivators |
Analysis |
Recurrence |
Risk factors |
Thrombophlebitis |
Blood
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Stegnar, Mojca | 05034 |
Peternel, Polona | 02112 |
Keber, Dušan, 1947- | 00373 |
Vene, Nina | 05888 |
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