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  • Encim telomeraza - tarča za prihodnja zdravila? = Telomerase - future drug target enzyme?
    Langerholc, Tomaž, 1977-
    Eucaryotic chromosome endings (telomeres) replication problem was solved in the 1980's by discovery of the telomerase enzyme. The Nobel Prize in Physiology or Medicine was awarded in 2009 for the ... discovery of telomerase. Altered telomerase expression in cancer, and human dream of eternal youth haveaccelerated the development of pharmacological telomerase inhibitors and activators. However, after 15 years of development they are still not available on the market. In the present article we reviewed pharmacological agents that target telomerase activity, which have entered clinical trials. Current drugs in development are mostly not intended to be used alone, as telomerase inhibitors under clinical trials are used in combination with the existing chemotherapeutics and anti-telomerase vaccines in combination with immuno-stimulants. Apart from cancer and aging, there are other diseases linked to deregulated activity of telomerasežtelomeres and we also discuss technical and legal problems that researchers encounter in developing anti-telomerase therapy. Given the pace of development, first anti-telomerase drugs might appear on the market in the next 5 years.
    Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 81, št. 6, jun. 2012, str. 493-499)
    Type of material - article, component part
    Publish date - 2012
    Language - slovenian
    COBISS.SI-ID - 263303936

    Link(s):

    Digitalna knjižnica Slovenije - dLib.si
    Digital Library of the University of Maribor – DLUM

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