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Curcumin, a curry spice ingredient, detects and differentiates between pathological tau inclusions in human histological brain sections = Kurkumin, sestavina začimbe curry, označuje vključke patološke beljakovine tau v histoloških rezinah človeških možganov in razločuje med njimi
Mohorko, Nina, 1980- ; Bresjanac, Mara
Background: Curcumin, a natural fluorochrome and a potent anti-inl ammatory antioxidant used as a spice and as an ayurvedic remedy for centuries, has beenshown to label pathologic aggregates of beta ...amyloid, alphasynuclein and scrapie prion protein, and to reduce their aggregation. Curcumin binding to tau, a protein that pathologically aggregates in a wide family of neurodegenerative diseases, tauopathies, has not been examined, yet. Our studywas aimed at assessing curcumin labelling of characteristic pathological deposits of hyperphosphorylated tau protein in brain sections from representative cases of three major classes of tauopathies: Alzheimerćs disease (AD; class 1), progressive supranuclear palsy (PSP; class 2) and Pickćs disease (PiD; class 3).Methods: The structures of interest were first identified in HE-stained sections and photographed. Subsequently, the visualization of these structures with curcumin and AT8 immunol uorescence was assessed by sequential labelling and computer-assisted photography of the same loci. Results were expressed as percentage of structures labelled. Results: Curcumin detected i brillar tau in AD (95 %) and PSP (90 %), but notin PiD. When comparing curcumin labelling to AT8 immunol uorescence in AD and PSP, curcumin labelled i brillar AT8-positive, but not non-fibrillar AT8-immunol uorescent structures. Curcumin also labelled extracellular fibrillar tangles remaining after neuronal death in AD and PSP, which were notvisualized by AT8 immunol uorescence.Conclusions: Curcumin fluorescence was shown to dif erentiate between pathological tau deposits in two ways. Firstly, it preferentially detected tau deposits with i brillar morphology. Secondly, curcumin also differentiated between representative cases of main tauopathy classes: it did not reveal fibrillar Pick bodies, while clearly labelling neurofibrillar tangles found in AD and PSP.
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