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Stranski učinki bioloških zdravil pri vnetnih revmatičnih boleznih = Side effects of biological therapy used in inflammatory rheumatic diseases
Gradišnik, Suzana, 1966- ...
Uvedba zaviralcev dejavnika tumorske nekroze (TNF) alfa predstavlja pomemben napredek obravnave bolnikov z revmatoidnim artritisom. Poročila o primerih tuberkuloze, drugih resnih okužbah, kongestivni ...srčni odpovedi, malignomih in avtoimunih obolenjih podajajo sum o varnosti njihove uporabe. Pri vseh treh uporabljanih zaviralcih TNF alfa je povečano tveganje reaktivacije tuberkuloze. Po podatkih iz literature je povečano tveganje obolevanja za limfomi ne-Hodgkinovega tipa, ki je podobno tveganju pri bolnikih za RA, ki se zdravijo z drugimi zdravili. Ni podatkov o povečanem tveganju za nastanek solidnih tumorjev. Zaenkrat tudi ni dokazanega vpliva na izid nosečnosti ali teratogenem učinku.
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