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Biološka zdravila pri zdravljenju astme = Biologic drugs in asthma treatmentBerce, Vojko ; Krajnc, Ivan, 1948- ; Potočnik, Uroš, 1969-Development of the new antiasthmatic drugs is directed ab ove all in the synthesis of the inhibitors of the proinflammatory cytokines and IgE antibodies. Several biologic drugs are tested for this ... purpose; most common ofthem are monoclonal antibodies or modified receptol-s. Experiments were alsodo ne with antiinflammatory cytokines, chemokine inhibitors, antilymphocytic antibodies, cell adhesion blockers and CpG oligonucleotides. The most promising drugs are those directed against interleukines IL-4, IL-S, IL-13, cytokine TNFa and IgE immunoglobulin. Humanized monoclonal antibody directed against immunoglobulin E binding site is the only biologic drug whichis already us ed in the asthma treatment. Better understanding of the molecular mechanisms of asthma leads to the identification of the new therapeutic targets.Source: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 49, št. 1, 2010, str. 11-18)Type of material - article, component partPublish date - 2010Language - slovenianCOBISS.SI-ID - 26741721
Author
Berce, Vojko |
Krajnc, Ivan, 1948- |
Potočnik, Uroš, 1969-
Topics
Asthma |
Drug Therapy |
Antibodies, Monoclonal |
Ige |
Interleukin-5 |
Interleukin-4 |
Interleukin-10 |
Interleukin-13 |
Tumor Necrosis Factor |
Inflammation Mediators |
Protitelesa monoklonska |
Interlevkin-5 |
Astma |
Interlevkin-4 |
IgE |
Tumor nekrotizirajoči faktor |
Interlevkin-13 |
Vnetje, posredniki |
Interlevkin-10
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Berce, Vojko | 33666 |
Krajnc, Ivan, 1948- | 02053 |
Potočnik, Uroš, 1969- | 16340 |
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