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Bone tissue engineering with human stem cellsMarolt Presen, Darja ; Knežević, Miomir ; Vunjak-Novakovic, GordanaTreatment of extensive bone defects requires autologous bone grafting or implantation of bone substitute materials. An attractive alternative has been to engineer fully viable, biological bone grafts ... in vitro by culturing osteogenic cells within three-dimensional scaffolds, under conditions supporting bone formation. Such grafts could be used for implantation, but also as physiologically relevant models in basic and translational studies of bone development, disease and drug discovery. A source of human cells that canbe derived in large numbers from a small initial harvest and predictably differentiated into bone forming cells is critically important for engineeringhuman bone grafts. We discuss the characteristics and limitations of various types of human embryonic and adult stem cells, and their utility for bone tissue engineering.Source: Stem cell research & therapy. - ISSN 1757-6512 (Letn. 1, 2010, str. 1-10)Type of material - e-articlePublish date - 2010Language - englishCOBISS.SI-ID - 27069657
Author
Marolt Presen, Darja |
Knežević, Miomir |
Vunjak-Novakovic, Gordana
Topics
Bone Transplantation |
Bone Substitutes |
Biomedical Engineering |
Osteogenesis |
Periosteum |
Stem Cells |
Bone Development |
Phenotype |
Osteogeneza |
Kost, presaditev |
Kost, nadomestki |
Pokostnica |
Biomedicinska tehnologija |
Matične celice |
Kost, razvoj |
Fenotip
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Database name | Field | Year |
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Marolt Presen, Darja | 22646 |
Knežević, Miomir | 10038 |
Vunjak-Novakovic, Gordana | ![]() |
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