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Influence of non-measurable disease on progression-free survival in patients with metastatic breast cancerGoldvaser, Hadar ...The presence of non-measurable disease is common in metastatic breast cancer. It is unknown whether treatment effect on progression free survival (PFS) is consistent among patients with measurable ... and non-measurable disease. Methods: A systematic literature search identified phase III randomized controlled trials (RCTs) in metastatic breast cancer that reported outcomes in patients with non-measurable and measurable disease. Hazard ratios (HRs) and 95% confidence intervals were computed to compare the individual trial treatment effect on PFS in non-measurable versus measurable disease. Analyses were repeated for boneonly compared to non-bone-only disease and based on drug mechanism of action. Results: Among 82 RCTs that enrolled patients with non-measurable disease, data were available from 16 trials comprising 8516 patients. Treatment effect on PFS was similar in patients with non-measurable and measurable disease (HR for intra-study comparison = 1.01, p = 0.82). However, compared to non-boneonly disease, a significantly greater effect on PFS was seen in those with bone-only disease (HR 0.83, p = 0.03). Compared to patients with measurable disease, there was a greater effect on PFS in those with non-measurable disease in RCTs of signal transduction inhibitors and endocrine therapy (HR 0.74, p = 0.01) and a lesser effect on PFS in RCTs of antiangiogenic drugs (HR 1.34, p = 0.02). Comparable effect on PFS was shown in RCTs evaluating endocrine therapy (HR 1.13, p = 0.23) and chemotherapy (HR 0.73, p = 0.22). Conclusions: There is variability in treatment effect on PFS in patients with measurable and nonmeasurable disease, especially those with bone-only disease. Standardization of PFS determination in these patients is warranted.Source: Cancer treatment reviews. - ISSN 0305-7372 (Vol. 59, Sep. 2017, str. 46-53)Type of material - article, component partPublish date - 2017Language - englishCOBISS.SI-ID - 2740859
Author
Goldvaser, Hadar |
Ribnikar, Domen |
Fazelzad, Rouhi |
Šeruga, Boštjan, 1973- |
Templeton, Arnoud J. |
Ocaña, Alberto |
Amir, Eitan
Topics
bone-only disease |
metastatic breast cancer |
measurable disease |
progression-free survival |
rak dojke |
metastaze |
kosti |
napredovanje bolezni |
preživetje
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Goldvaser, Hadar | ![]() |
Ribnikar, Domen | 36202 |
Fazelzad, Rouhi | ![]() |
Šeruga, Boštjan, 1973- | 24577 |
Templeton, Arnoud J. | ![]() |
Ocaña, Alberto | ![]() |
Amir, Eitan | ![]() |
Source: Personal bibliographies
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