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Caffeine-sensitive calcium stores regulate synaptic transmission from retinal rod photoreceptorsKrižaj, David ...We investigated the role of caffeine-sensitive intracellular stores in regulating intracellular calcium (šCa(2+)đ(i)) and glutamatergic synaptic transmission from rod photoreceptors. Caffeine ... transiently elevated and then markedly depressed šCa(2+)đ(i) to below prestimulus levels in rod inner segments and synaptic terminals. Concomitant with the depression was a reduction of glutamate release and a hyperpolarization of horizontal cells, neurons postsynaptic to rods. Caffeine did not affect the rods' membrane potentials indicating that caffeine likely acted via some mechanism(s) other than a voltage-dependent deactivation of the calcium channels. Most of caffeine's depressive action on šCa(2+)đ(i), on glutamate release, and on I(Ca) in rods can be attributed to calcium release from stores: (1) caffeine'sactions on šCa(2+)đ(i) and I(Ca) were reduced by intracellular BAPTAand barium substitution for calcium, (2) other nonxanthine store-releasing compounds, such as thymol and chlorocresol, also depressed šCa(2+)đ(i), and (3) the magnitude of šCa(2+)đ(i) depression depended on basalšCa(2+)đ(i) before caffeine. We propose that caffeine-released calcium reduces I(Ca) in rods by an as yet unidentified intracellular signaling mechanism. To account for the depression of šCa(2+)đ(i) below rest levels and the increased fall rate of šCa(2+)đ(i) with higher basal calcium, we also propose that caffeine-evoked calcium release from stores activates a calcium transporter that, via sequestration into stores or extrusion, lowers šCa(2+)đ(i) and suppresses glutamate release. The effects of store-released calcium reported here operate at physiological calcium concentrations, supporting a role in regulating synaptic signaling in vivo.Source: The Journal of neuroscience. - ISSN 0270-6474 (Letn. 19, št. 17, 1999, str. 7249-7261)Type of material - article, component partPublish date - 1999Language - englishCOBISS.SI-ID - 27529433
Author
Križaj, David |
Bao, Jian-Xin |
Schmitz, Yvonne |
Witkovsky, Paul |
Copenhagen, David R.
Topics
Ambystoma |
Animals |
Barium |
Pharmacology |
Caffeine |
Pharmacology |
Calcium |
Physiology |
Calcium Channels |
Physiology |
Chelating Agents |
Pharmacology |
Cresols |
Pharmacology |
Egtazic Acid |
Analogs & Derivatives |
Pharmacology |
Electrophysiology |
Kinetics |
Models, Neurological |
Presynaptic Terminals |
Drug Effects |
Physiology |
Ryanodine |
Pharmacology |
Synaptic Transmission |
Drug Effects |
Physiology |
Thymol |
Pharmacology |
Xenopus Laevis |
Živali |
Helati |
Egtazinska kislina |
Predsinaptični končiči |
Rianodin |
Modeli nevrološki |
Sinaptični prenos |
Timol |
Ambystoma |
Kofein |
Kalcij |
Krezoli |
Kinetika |
Kalcijevi kanalčki |
Barij |
Elektrofiziologija |
Xenopus laevis
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Križaj, David | 07133 |
Bao, Jian-Xin | ![]() |
Schmitz, Yvonne | ![]() |
Witkovsky, Paul | ![]() |
Copenhagen, David R. | ![]() |
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