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13.
Solubility dependence of selected active substances
Resman, Aleksander ...
The solubility of substances, depending on properties of both the solute and the solvent, is one the most critical parameters in pharmaceutical technology.For accurate measurements, the solubility ...characteristics of a particular substance must be well established. The solubility dependence on hydrate formation, polymorphism and particle size were investigated in the cases of cimetidine hydrochloride, clindamycin phosphate, pefloxacin methanesulphonate, cimetidine, and nifedipine. A simple mathematical model was used to describe dissolution profiles of solvates and polymorphs. It was observed that the solubilities of substances under investigation were in most cases affected by one of the aforementioned factors.
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