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  • Dynamic contrast-enhanced CT of head and neck tumors : comparison of first-pass and permeability perfusion measurements using two different commercially available tracer kinetics models
    Bisdas, Sotirios ...
    Rationale and objectives: To evaluate the interchangeability of perfusion parameters between two software packages for the postprocessing of dynamic contrast-enhanced (DCE) computed tomographic ... images of head and neck tumors. Materials and methods: DCE computed tomographic images of 75 patients with head and neck tumors were postprocessed using a software package based on the maximum-slope approach and Patlak analysis, as well as a software package withdeconvolution-based analysis incorporating an adiabatic approximation of tissue homogeneity (ATH) model. The evaluated perfusion parameters included blood flow (F), blood volume (v), and permeability-surface area product (PS). Region-of-interest (ROI) analysis of the tumors and the metastatic lymph nodeswas performed. The perfusion parameters were compared using the Wilcoxon matched-pairs test and Bland-Altman plots. Results: One hundred fifty-two ROIsof tumors and nodes were outlined and analyzed. Moderate to good correlations were demonstrated between the various perfusion values (r = 0.56-0.72, P < .0001). The Wilcoxon test revealed a significant difference between the two methods (P < .001), with the F, v, and PS values obtained using the maximum-slope approach and Patlak analysis higher than those obtained using deconvolution-based analysis with the assumptions of the ATH model. The Bland-Altman plots for F and v values revealed a proportionality trend with outliers, which were strongly associated with the magnitudes of theparameters. Analysis of the PS values did not show any systematic bias. Conclusion: There were significant differences in the perfusion parameters obtained using the two software packages, and thus, these parameters are not directly interchangeable.
    Source: Academic radiology. - ISSN 1076-6332 (Vol. 15, no. 12, 2008, str. 1580-1589)
    Type of material - article, component part
    Publish date - 2008
    Language - english
    COBISS.SI-ID - 27884505
    DOI

source: Academic radiology. - ISSN 1076-6332 (Vol. 15, no. 12, 2008, str. 1580-1589)
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