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  • Variabilnost elektrokardiograma po presaditvi srca : doktorsko delo
    Samarin Lovrič, Silvia
    Objective: During the heart transplantation procedure, allograft becomes completely denervated. Partial ventricular sympathetic reinnervation may develop one year or later after the transplantation ... and is of functional significance. The relation between sinus node sympathetic reinnervation and left ventricular sympathetic reinnervation is not known. Aim of our study was to assess sympathetic reinnervation of sinus node and left ventricle and to evaluate their time dependence. MethodsČ Two independent non-invasive methods were usedČ sympathetic reinnervation was evaluated with RR interval variability analysis and left ventricular sympathetic reinnervation was evaluated with iodine-123-meta-iodobenziylguanidine (123-IMIBG) scintigraphy. Twelve patients and 14 healthy controls were studied. Bipolar ECG with high sampling rate and resolution was recorded over 8.5 minutes in supine and in upright position. RR intervals in time domain and in frequency domain were analysed to evaluate sinus node reinnervation. Spectral power in low frequency(LF) range (0.04-O.15Hz) above 4.5 ms2 was considered as sinus node sympathetic reinnervation. Patients were divided in groups with sinus node sympathetic reinnervation (LF>4.5 ms2) and without sinus node sympathetic reinnervation (LF<4.5 ms2). In patients, 123-I-MIBG scintigraphy was performed. Heart to mediastinum ratio (HMR) was calculated and patients were divided in groups with left ventricular reinnervation (HMR>1.3) and without left ventricular reinnervation (HMR<1.3). The results of both methods were compared and the coexistence of sinus node sympathetic reinnervation and left ventricular sympathetic reinnervation was evaluated. Blood sample for plasma catecholamine levels was taken in supine body position in patients, just before 123-I-MIBG injection. (Abstract truncated at 2000 characters)
    Type of material - dissertation
    Publication and manufacture - Ljubljana : [S. Samarin Lovrič], 2005
    Language - slovenian
    COBISS.SI-ID - 2800404

Library/institution City Acronym For loan Other holdings
MF, Central Medical Library, Ljubljana Ljubljana CMK outside loan 2 cop.
National and University Library, Ljubljana Ljubljana NUK reading room 1 cop.
University of Maribor Library Maribor UKM reading room 1 cop.
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