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A right-to-left shunt in children with arterial ischaemic strokePerković-Benedik, Mirjana ...Objective: To compare the prevalence and grade of right-to-left shunt (RLS) inchildren with arterial ischaemic stroke (AIS) and in controls. Design: Prospective study. Sstting: Tertiary paediatric ... referral centre. Patients 30 consecutive children with AIS. Intervention: Contrast transcranial Doppler (cTCD) with Valsalva manoeuvre was performed in children with AIS and in controls. Main outcome measures: Detection and quantification of RLS. Results:Logistic regression analysis showed that RLS was significantly associated with AIS and prothrombotic disorders or with AIS of undetermined aetiology (OR 6.10; 95% CI 1.41 to 26.3; p=0.015). The prevalence of RLS was significantly higher in a group of children with AIS and prothrombotic disorders or with AIS of undetermined aetiology compared to controls (p<0.05).Significantly more microembolic signals (MES) were detected in a group of children with AIS and prothrombotic disorders or with AIS of undetermined aetiology than in controls (p<0.005). Conclusions: Both the prevalence of RLS and number of detected MES were significantly higher in a group of children with AIS and prothrombotic disorders or with AIS of undetermined aetiology compared to controls. These findings suggest that paradoxical embolism may be an underestimated cause of AIS in children, particularly those with AIS and prothrombotic disorders or with AIS of undetermined aetiology.Source: Archives of Disease in Childhood. - ISSN 0003-9888 (Vol. 96, issue 5, 2011, str. 461-467)Type of material - article, component partPublish date - 2011Language - englishCOBISS.SI-ID - 28563417
Author
Perković-Benedik, Mirjana |
Zaletel, Marjan, 1963- |
Pečarič-Meglič, Nuška |
Podnar, Tomaž
Topics
Heart Septal Defects, Atrial |
Cerebral Infarction |
Embolism, Paradoxical |
Cerebral Ischemia |
Ultrasonography, Doppler, Transcranial |
Magnetic Resonance Angiography |
Logistic Models |
Child |
Child |
Valsalva'S Maneuver |
Srce, pretin, defekti preddvorni |
Ultrasonografija dopplerska, transkranialna |
Možganski infarkt |
Embolija paradoksna |
Magnetna resonanca, angiografija |
Otrok |
Logistični modeli |
Valsalvin manever
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Database name | Field | Year |
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Perković-Benedik, Mirjana | 35093 |
Zaletel, Marjan, 1963- | 11647 |
Pečarič-Meglič, Nuška | 20710 |
Podnar, Tomaž | 23760 |
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