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Antitumor in situ vaccination effect of TNF[alfa] and IL-12 plasmid DNA electrotransfer in a murine melanoma modelKamenšek, Urška ...Gene electrotransfer (GET) is one of the most efficient non-viral gene therapy approaches for the localized transfer of multiple genes into tumors in vivo; therefore, it is especially promising for ... delivering different cytokines that are toxic if administered systemically. In this study, we used concomitant intratumoral GET of two cytokines: tumor necrosis factor alpha (TNF%), a potent cytotoxic cytokine to induce in situ vaccination, and interleukin 12 (IL-12), an immunostimulatory cytokine to boost the primed local immune response into a systemic one. After performing GET in murine melanoma tumors, both TNF% and IL-12 mRNA levels were significantly increased, which resulted in a pronounced delay in tumor growth of 27 days and a prolonged survival time of mice. An antitumor immune response was confirmed by extensive infiltration of immune cells in the tumor site, and expansion of the effector immune cells in the sentinel lymph nodes. Furthermore, the effect of in situ vaccination was indicated by the presence of vitiligo localized to the treatment area and resistance of the mice to secondary challenge with tumor cells. Intratumoral GET of two cytokines, one for in situ vaccination and one for an immune boost, proved feasible and effective in eliciting a potent and durable antitumor response; therefore, further studies of this approach are warranted.Source: Cancer immunology and immunotherapy. - ISSN 0340-7004 (Vol. 67, no. 5, 2018, str. 785-795)Type of material - article, component partPublish date - 2018Language - englishCOBISS.SI-ID - 2877819
Author
Kamenšek, Urška |
Čemažar, Maja |
Lampreht Tratar, Urša |
Uršič Valentinuzzi, Katja, 1990- |
Serša, Gregor
Topics
elektroprenos genov |
interlevkin 12 |
melanom |
glodalci |
gene electroporation |
interleukin 12 |
melanoma |
murine
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kamenšek, Urška | 28387 |
Čemažar, Maja | 14575 |
Lampreht Tratar, Urša | 36367 |
Uršič Valentinuzzi, Katja, 1990- | 38223 |
Serša, Gregor | 08800 |
Source: Personal bibliographies
and: SICRIS
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