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Sottopopolazioni di anticorpi anti-ß[sub]2glicoproteina I con diverso potenziale patogenetico : fine specificita` nei confronti dei domini della ß[sub]2glicoproteina I = Subpopulations of anti-ß[sub]2glycoprotein I antibodies with different pathogenic potential : fine specificity against the domains of ß[sub]2glycoprotein I
Andreoli, L. ...
Objective: Anti-betaglycoprotein I antibodies (a-betaGPI) are a laboratory criterion for the antiphospholipid syndrome (APS) and were demonstrated to be involved in the pathogenesis of APS. However, ...they can also be detected in asymptomatic subjects. It has been suggested that a-betaGPI against Domain1 (D1) associate with thrombosis, while those recognizing Domain4/5 (D4/5) havebeen identified in non-thrombotic conditions. We evaluate the specificity of a-betaGPI in different clinical situations. Methods: We studied 39 one-year-old healthy children born to mothers with systemic autoimmune diseases (SAD) (15 (38.4%) were born to mothers who were a-betaGPI positive), 33 children with atopic dermatitis (AD) and 55 patients with APS (50 adults and 5 paediatrics). All subjects were IgG a-betaGPI positive. IgG a-betaGPI were performed by homemade ELISA, while IgG a-betaGPI D1 and D4/5 were tested on research ELISAs containing recombinant betaGPI domains antigens. Results: One-year-old children and AD children displayed preferential reactivity for D4/5; patients with APS recognized preferentially D1. We also found a good correlation between a-betaGPI and D4/5 in one-year-old (r=0.853) and AD children (r=0.879) and between a-betaGPI and D1 in the APS group (r=0.575). No thrombotic events were recorded in both groups of children. Conclusion: A-betaGPI found in non-thrombotic conditions (healthy children born to motherswith SAD and AD children) mostly recognize D4/5, in contrast to the prevalent specificity for D1 in the APS group. The different specificity couldat least partially explain the "innocent" profile of a-betaGPI in children.
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