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Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in miceD'Adamo, Patrizia ...Non-specific mental retardation (NSMR) is a common human disorder characterized by mental handicap as the only clinical symptom. Among the recently identified MR genes is GDI1, which encodes alpha ... Gdi, one of the proteins controlling the activity of the small GTPases of the Rab family in vesicle fusion and intracellular trafficking. We report the cognitive and behavioral characterization of mice carrying a deletion of Gdi1. The Gdi1-deficient mice are fertile and anatomically normal. They appear normal also in many tasks to assess spatial and episodic memory and emotional behavior. Gdi1-deficient mice are impaired in tasks requiring formation of short-term temporal associations, suggesting a defect in short-term memory. Inaddition, they show lowered aggression and altered social behavior. In mice,as in humans, lack of Gdi1 spares most central nervous system functions and preferentially impairs only a few forebrain functions required to form temporal associations. The general similarity to human mental retardation is striking, and suggests that the Gdi1 mutants may provide insights into the human defect and into the molecular mechanisms important for development of cognitive functions.Source: Human molecular genetics. - ISSN 0964-6906 (Vol. 11, issue 21, 2002, str. 2567-2580)Type of material - article, component partPublish date - 2002Language - englishCOBISS.SI-ID - 29056729
Author
D'Adamo, Patrizia |
Welzl, Hans |
Papadimitriou, Stavros |
Barletta, Marina Raffaele, di
Topics
Memory |
Social Behavior |
Animals |
Brain |
Cytology |
Gene Deletion |
In Situ Hybridization |
Mental Retardation |
Genetics |
Mice |
Mice, Knockout |
Spomin |
Socialno vedenje |
Živali |
Miši |
Možgani |
In situ hibridizacija |
Duševna zaostalost |
Miši Knockout |
Genska delecija
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D'Adamo, Patrizia | 33901 |
Welzl, Hans | ![]() |
Papadimitriou, Stavros | ![]() |
Barletta, Marina Raffaele, di | ![]() |
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