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Pineal cysts - a benign consequence of mild hypoxia in a near-term brain?Bregant, Tina, 1975- ...Background: Pineal cysts are benign glial uniloculated or multiloculated fluid-filled sacs located in the pineal gland region. Small pineal cysts are often found incidentally in healthy adults in ... 1.5-10.8%. Large cysts may causeneurological problems due to pressure exertion on adjacent structures. Methods: We have used prospective, observational study of an inception cohort of 16 adolescents of mean age 21.69 years (SD= 0.87) with mild (68.7%) to moderate (31.3%) HIE: 7 girls (43.8%) and 9 (56.3%) boys, born with mean gestational age of 35.75 weeks (SD= 3.80) and mean birthweight of 2 644 g (SD=815). HIE was confirmed by presence of abnormal CTG and/or meconium and/orApgar scores less than 7 at 5 minutes and/or need for resuscitation and/or cord pH less than 7.2 and /or BE more than -15. The clinical assessmentof HIE was done according to the Sarnat-Sarnat scoring. Neonatal data, including EEG and imaging data, were collected. Adolescents were scannedwith 3T Magnetom Trio Tim, Siemens, head coil 12 channels, regular sequences and sagittal 3D magnetization-prepared rapid acquisition gradient echo (MPRAGE) sequence with voxel size 1 mm3. Neurological outcome was determined. Results: In 1 patient we found cortical dysplasia and 1 had a panic attack hence their data were omitted. In the group of 14 we have incidentally found in 5 patients a larger, asymptomatic pineal cysts with the overall incidence of 36%. Other MR findings in the group were in 50% white matter injury, in 50% thinner corpus callosum. No statistically significant difference between neonatal cUS and late follow-up MRI (p=0.881) was found. Correlation was not significant with Spearman correlation koefficient 0.201. Presence of pineal cysts was linked to thinner corpus callosum (p=0.005). Conclusions: We propose that larger pineal cyst, in the absence of other imaging findings except for thinner corpus callosum, is a benign consequence of mild hypoxia in a near-term brain.Source: Neuro-endocrinology letters. - ISSN 0172-780X (Vol. 35, no. 5, 2011, str. 101-104)Type of material - article, component partPublish date - 2011Language - englishCOBISS.SI-ID - 29350105
Author
Bregant, Tina, 1975- |
Radoš, Milan |
Derganc, Metka |
Neubauer, David |
Kostović, Ivica, 1943-
Topics
Pineal Body |
Cysts |
Anoxia |
Cerebral Ischemia |
Gestational Age |
Infant, Newborn |
Adolescence |
Birth Weight |
Apgar Score |
Asphyxia Neonatorum |
Electroencephalography |
Prospective Studies |
Epifiza, možgani |
Ciste |
Gestacijska starost |
Anoksija |
Prospektivne študije |
Adolescenca |
Novorojenček |
Porodna teža |
Apgar, točkovanje |
Asfiksija novorojenčka |
Elektroencefalografija
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Bregant, Tina, 1975- | 24470 |
Radoš, Milan | |
Derganc, Metka | 02148 |
Neubauer, David | 09180 |
Kostović, Ivica, 1943- |
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