-
MR perfusion and diffusion imaging in the follow-up of recurrent glioblastoma treated with dendritic cell immunotherapy : pilot studyVrabec, Matej, radiolog, 1977- ...Introduction: This study aims to determine the potential value of MR-PWI and MR-DWI to differentiate immune therapy-induced inflammatory response from recurrent glioblastoma tumour growth. Both can ... present as contrast-enhancing lesions on conventional magnetic resonance imaging (MRI). Methods: Patients with recurrent glioblastoma who could obtain a total or near-total resection were treated with dendritic cell immune therapy according to the HGG-IMMUNO-2003 trial. A retrospective analysis of 32 follow-up MRI examinations (mean follow-up time 21 months) in eight patients was performed for this pilot study. For the statistical analysis, the 32 examinations were divided into three groups: 0-obtained in patients that remained stable during the follow-up period, 1a-obtained in progressive-tumour patients at time points before definite progression and 1b-obtained in patients at or after progression. Results: Maximum lesional rCBV ratios were highest in group 1b (Student t test, 9.25 +/- 2.68; p < 0.001) and were higher in group 1a (4.87 +/- 1.61, p < 0.001) compared to group 0 (1.22 +/- 0.47). The minimum apparentdiffusion coefficients (ADCs) in the contrast-enhancing regions were lower in group 1a (0.62 +/- 0.06 x 10(-3) mm(2)/s) than in group 0 (1.03 +/- 0.43 x 10(-3) mm(2)/s, p = 0.01) and higher in group 1b (0.76 +/- 0.08) compared to 1a (p = 0.02). The minimum ADCs in the FLAIR-hyperintense region were lower in group 1a (0.62 +/- 0.06, p = 0.02) compared to group 0 (0.76 +/-0.16) but not significantly different in group 1b (0.68 +/- 0.07) from groups 0 and 1a (p = 0.33, p = 0.10). The mean ADCs of the FLAIR-hyperintense region and the mean ADCs of the contrast-enhancing lesion were not significantly different. (Abs. trunc. at 2000 ch.)Source: Neuroradiology. - ISSN 0028-3940 (Vol. 53, iss. 10, 2011, str. 721-731)Type of material - article, component partPublish date - 2011Language - englishCOBISS.SI-ID - 29620697
Author
Vrabec, Matej, radiolog, 1977- |
Van Cauter, Sofie |
Himmelreich, Uwe |
Šuput, Dušan
Topics
Dendritic Cells |
Adult |
Brain |
Pathology |
Brain Neoplasms |
Pathology |
Therapy |
Contrast Media |
Follow-Up Studies |
Glioblastoma |
Pathology |
Therapy |
Image Enhancement |
Immunotherapy |
Methods |
Perfusion |
Pilot Projects |
Treatment Outcome |
Dendritične celice |
Imunoterapija |
Odrasli |
Glioblastom |
Možgani |
Kontrastna sredstva |
Perfuzija |
Slika, povečanje |
Zdravljenje, izid |
Možganske novotvorbe |
Sledilne študije |
Pilotski projekti
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Vrabec, Matej, radiolog, 1977- | 28076 |
Van Cauter, Sofie | ![]() |
Himmelreich, Uwe | ![]() |
Šuput, Dušan | 07002 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.