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Tolerogene dendritične celice pridobljene z visokimi odmerki interferona-gama : SI 23342 A (28. 10. 2011)Švajger, Urban ; Obermajer, Nataša ; Jeras, MatjažTekom intenzivnih študij, ki so pripeljale do predlozenega izuma, so tukajšnji izumitelji ugotovili, da dendritične celice, gojene v prisotnosti visokih koncentracij IFN-y delujejo tolerogeno ter ... imajo zmanjšano sposobnost indukcije proliferacije alogenskih CD4+ celic Tin vitro, proizvajajo nizke kolicine IL-12p70, inducirajo alogenske naivne CD4+ celice T, da postanejo IFN-lizko IL-l 0 proizvajajoce CD4+ celice T ter zavirajo nastajanje IFN-y v aktiviranih alogenskih CD4+ celicah T. Predlozeni izum torej po prvem vidiku zagotavlja pripravo tolerogenih dendritičnih celic, obdelanih z visokimi odmerki (> 500 U/ml) IFN-y. Predloženi izum zagotavlja tudi uporabo z IFN-y induciranih tolerogenih dendritičnih celic za preprečevanje in zdravljenje bolezni oz. stanj, pri katerih je indicirana uporaba imunosupresivov.Takšna stanja predstavljajo zlasti avtoimunske bolezni, astma ter stanja po alogenski transplantaciji celic, organov in tkiv.Type of material - patentPublication and manufacture - Ljubljana : Urad RS za intelektualno lastnino, 2011Language - slovenianCOBISS.SI-ID - 2999921
Author
Švajger, Urban |
Obermajer, Nataša |
Jeras, Matjaž
Topics
interferon gama |
dendritične celice
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Švajger, Urban | 26198 |
Obermajer, Nataša | 25494 |
Jeras, Matjaž | 01302 |
Source: Personal bibliographies
and: SICRIS
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