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Frequency dependent effect of selective biphasic left vagus nerve stimulation on heart rate and arterial pressureMirković, Tomislav, 1963 ...Activation of the parasympathetic pathway leads to negative chronotropic, dromotropic, and inotropic changes of heart function. The ability to selectively stimulate certain superficial compartments ... of peripheral nerves has been demonstrated previously. The aim of the present study was to find a clinically acceptable selective biphasic vagus nerve stimulation technique, which could allow gradual regulation of heart rate and systemic arterial pressure. In two patients, the left vagus nerve was stimulated with a combination of quasi-trapezoidal cathodic and rectangular anodic current pulses with different stimulation frequencies (10Hz, 20Hz, 30Hz) and increasing current. The heart rate and systemic arterial pressure decreased with increasing current at all different stimulation frequencies (p<0.05). Theheart rate and arterial pressure response was more gradual with 10Hz compared to 20Hz/30Hz vagus nerve stimulation (p<0.05). In conclusion, selective vagus nerve stimulation, with a combination of quasi-trapezoidal cathodic and rectangular anodic current pulses at 10Hz, offers gradual heart rate and systolic arterial pressure control.Source: Signa vitae : specialized medical journal. - ISSN 1334-5605 (Vol. 7, iss. 2, 2012, str. 63-68)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 30304985
Author
Mirković, Tomislav, 1963 |
Kneževič, Ivan, 1962- |
Radan, Ivan |
Rozman, Janez, 1956- |
Geršak, Borut |
Podbregar, Matej
Topics
Vagus Nerve |
Electric Stimulation |
Heart Rate |
Blood Pressure |
Echocardiography |
Endarterectomy, Carotid |
Coronary Artery Bypass |
Vagus živec |
Ehokardiografija |
Srčna frekvenca |
Krvni pritisk |
Električna stimulacija |
Endarterektomija karotidna |
Koronarna arterija, obvoz
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Mirković, Tomislav, 1963 | 20878 |
Kneževič, Ivan, 1962- | 21974 |
Radan, Ivan | ![]() |
Rozman, Janez, 1956- | 04293 |
Geršak, Borut | 04768 |
Podbregar, Matej | 21806 |
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