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Molecular signalling towards mitochondrial breakdown is enhanced in skeletal muscle of patients with chronic obstructive pulmonary disease (COPD) [Elektronski vir]Leermakers, Pieter A. ...Loss of skeletal muscle mitochondrial oxidative capacity is well-established in patients with COPD, but the role of mitochondrial breakdown herein is largely unexplored. Currently, we studied if ... mitochondrial breakdown signalling is increased in skeletal muscle of COPD patients and associates with the loss of mitochondrial content, and whether it is affected in patients with iron deficiency (ID) or systemic inflammation. Therefore, mitophagy, autophagy, mitochondrial dynamics and content markers were analysed in vastus lateralis biopsies of COPD patients (N%=%95, FEV1% predicted: 39.0 [31.0-53.6]) and healthy controls (N%=%15, FEV1% predicted: 112.8 [107.5-125.5]). Sub-analyses were performed on patients stratified by ID or C-reactive protein (CRP). Compared with controls, COPD patients had lower muscle mitochondrial content, higher BNIP3L and lower FUNDC1 protein, and higher Parkin protein and gene-expression. BNIP3L and Parkin protein levels inversely correlated with mtDNA/gDNA ratio and FEV1% predicted. ID-COPD patients had lower BNIP3L protein and higher BNIP3 gene-expression, while high CRP patients had higher BNIP3 and autophagy-related protein levels. In conclusion, our data indicates that mitochondrial breakdown signalling is increased in skeletal muscle of COPD patients, and is related to disease severity and loss of mitochondrial content. Moreover, systemic inflammation is associated with higher BNIP3 and autophagy-related protein levels.Source: Scientific reports [Elektronski vir]. - ISSN 2045-2322 (Vol. 8, no. 1, 2018, str. 1-13)Type of material - e-articlePublish date - 2018Language - englishCOBISS.SI-ID - 3147131
Author
Leermakers, Pieter A. |
Schols, Annemie M. W. J. |
Kneppers, Anita E. M. |
Kelders, Marco C. J. M. |
Theije, Chiel C. de |
Lainščak, Mitja |
Gosker, Harry Reinier, 1973-
Topics
kronična obstruktivna pljučna bolezen |
mitohondriji |
skeletne mišice |
KOPB |
mitochondrial |
skeletal muscle |
COPD |
chronic obstructive pulmonary disease
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Leermakers, Pieter A. | |
Schols, Annemie M. W. J. | |
Kneppers, Anita E. M. | |
Kelders, Marco C. J. M. | |
Theije, Chiel C. de | |
Lainščak, Mitja | 22680 |
Gosker, Harry Reinier, 1973- |
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