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Resolution of HLA-B*44:02:01G, -DRB1*14:01:01G and -DQB1*03:01:01G reveals a high allelic variability among 12 European populationsVidan-Jeras, Blanka ...Within the framework of the EU-funded HLA-NET action, an analysis of three G-group alleles, HLA-B*44:02:01G, DRB1*14:01:01G and DQB1*03:01:01G, was undertaken in 12 European populations. Ambiguities ... were resolved by polymerase chain reaction-sequence-specific amplification (PCR-SSP) or PCR-sequence-based typing (PCR-SBT) in a total of 5095 individuals. The results of the DRB1*14:01/14:54 ambiguity showed high relative ratios (24-53%) of DRB1*14:01 in Bulgarians, Croatians, Greeks, Italians and Slovenians, contrasting with low ratios (6-13%) in Austrians, Finnish, French, Hungarians, Norwegians and Swiss. Resolution of the B*44:02/44:27 ambiguity showed that B*44:27 had a high relative ratio in Slovenians (25.5%) and Bulgarians (37%) and low in French and Swiss (0.02-1%), and was not observed in Greeks and Italians. The highest relative ratio of DQB1*03:19 was found in Portuguese (11%), by contrast with low ratios (0-3%) in the other five populations. Analysis of the A, B, DRB1 phenotypes and family-derived haplotypes in 1719 and 403 individuals positive for either HLA-B*44:02G or DRB1*14:01G ambiguities, respectively, showed some preferential associations, such as A*26%DRB1*14:01, B*35%DRB1*14:01, B*38%DRB1*14:01 and B*44:27%DRB1*16. Because these ambiguities are located outside the peptide-binding site, they may not be recognized by alloreactive T-cells. However, because of strong linkage disequilibrium (LD), the DRB1*14:01 vs DRB1*14:54 and the B*44:02 vs B*44:27 mismatches are associated to DRB3-, and C-mismatches, respectively. These results are informative for algorithms searching unrelated hematopoietic stem cell donors. For B*44:27-positive patients, searches are expected to be more successful when requesting donors from Southeastern-European ancestry. Furthermore, the introduction of human leukocyte antigen (HLA)-typing strategies that allow resolving exon 4 (for class I) and exon 3 (for class II) polymorphisms can be expected to contribute significantly to population genetics studies.Source: Tissue antigens. - ISSN 0001-2815 (Vol. 84, iss. 5, 2014, str. 459-464)Type of material - article, component partPublish date - 2014Language - englishCOBISS.SI-ID - 31914969
Author
Vidan-Jeras, Blanka |
Buhler, S. |
Dubois, V. |
Grubić, Zorana |
Ivanova, M., imunolog |
Jaatinen, T. |
Ligeiro, D. |
Lokki, M.-L. |
Papasteriades, C. |
Poli, F.
Topics
European populations |
human leukocyte antigen |
human leukocyte antigen incompatibilities |
Evropske populacije |
antigen humanih levkocitov |
človeški levkociti, antigen nezdružljivosti
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Vidan-Jeras, Blanka | 10453 |
Buhler, S. | ![]() |
Dubois, V. | ![]() |
Grubić, Zorana | ![]() |
Ivanova, M., imunolog | ![]() |
Jaatinen, T. | ![]() |
Ligeiro, D. | ![]() |
Lokki, M.-L. | ![]() |
Papasteriades, C. | ![]() |
Poli, F. | ![]() |
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