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Astrogliopathology in neurological, neurodevelopmental and psychiatric disordersVerkhratsky, Alexei ; Parpura, VladimirAstroglial cells represent a main element in the maintenance of homeostasis and providing defense to the brain. Consequently, their dysfunction underlies many, if not all, neurological, ... neurodevelopmental and neuropsychiatric disorders. General astrogliopathy is evident in diametrically opposing morpho-functional changes in astrocytes, i.e. their hypertrophy along with reactivity or atrophy with asthenia. Neurological disorders with astroglial participation can be genetic, of which Alexander disease is a primary sporadic astrogliopathy, environmentally caused, such as heavy metal encephalopathies, or neurodevelopmental in origin. Astroglia contribute to neurodegenerative processes seen in amyotrophic lateral sclerosis, Alzheimer's and Huntington's diseases. Furthermore, astroglia also play a role in major neuropsychiatric disorders, ranging from schizophrenia to depression, as well as in addictive disorders.Source: Neurobiology of disease. - ISSN 0969-9961 (Vol. 85, Jan. 2016, str. 254-261)Type of material - article, component partPublish date - 2016Language - englishCOBISS.SI-ID - 31937753
Author
Verkhratsky, Alexei |
Parpura, Vladimir
Topics
neuroglia |
astrocyte |
neurological diseases |
nevrologija |
astrocit |
nevrološke bolezni
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Verkhratsky, Alexei | 37641 |
Parpura, Vladimir |
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