Akademska digitalna zbirka SLovenije - logo
ALL libraries (COBIB.SI union bibliographic/catalogue database)
PDF
  • 3-Dimensional porous nanocomposite scaffolds based on cellulose nanofibers for cartilage tissue engineering [Elektronski vir] : tailoring of porosity and mechanical performance
    Naseri, Narges ...
    Fully bio-based 3-dimensional porous scaffolds based on freeze-dried cellulose nanofibers (70 - 90 wt%) stabilized using a genipin crosslinked matrix of gelatin and chitosan were prepared. Morphology ... studies using scanning electron microscopy showed that the scaffolds have interconnected pores with average pore diameters of 75 - 200 microm and nanoscaled pore wall roughness, both favorable for cell interactions with cartilage repair. X-ray tomography confirmed the 3-dimensional homogeneity and interconnectivity of the pores as well as the fi brillar structure of the scaffolds. The compression modulus of the scaffolds (1 - 3 MPa) at room conditions was higher than natural cartilage ( z 1 MPa). The lowered compression modulus of 10 % 60 kPa in phosphate buffered saline (PBS) at 37 °C was considered favorable for chondrogenesis. The current study therefore successfully addressed the challenge of tailoring the pore structure and mechanical properties simultaneously for cartilage regeneration. Furthermore, the sca ff olds' high porosity ( z 95%), high PBS uptake and good cytocompatibility towards chondrocytes are considered beneficial for cell attachment and extracellular matrix (ECM) production.
    Source: RSC advances [Elektronski vir]. - ISSN 2046-2069 (Vol. 6, iss. 8, 2016, str. 5999-6007)
    Type of material - e-article ; adult, serious
    Publish date - 2016
    Language - english
    COBISS.SI-ID - 32759513

    Link(s):

    http://pubs.rsc.org/en/content/articlepdf/2016/ra/c5ra27246g?page=search
    DOI

Shelf entry