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  • Circular RNAs [Elektronski vir] : biogenesis, function, and a role as possible cancer biomarkers
    Bolha, Luka ; Ravnik-Glavač, Metka ; Glavač, Damjan
    Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs) that form covalently closed continuous loop structures, lacking the terminal 5' and 3' ends. CircRNAs are generated in the process of ... back-splicing and can originate from different genomic regions. Their unique circular structure makes circRNAs more stable than linear RNAs. In addition, they also display insensitivity to ribonuclease activity. Generally, circRNAs function as microRNA (miRNA) sponges and have a regulatory role in transcription and translation. They may be also translated in a cap-independent manner in vivo, to generate specific proteins. In the last decade, next-generation sequencing techniques, especially RNA-seq, have revealed great abundance and also dysregulation of many circRNAs in various diseases, suggesting their involvement in disease development and progression. Regarding their high stability and relatively specific differential expression patterns in tissues and extracellular environment (e.g., body fluids), they are regarded as promising novel biomarkers in cancer. Therefore, we focus this review on describing circRNA biogenesis, function, and involvement in human cancer development and address the potential of circRNAs to be effectively used as novel cancer diagnostic and prognostic biomarkers.
    Source: International Journal of Genomics [Elektronski vir]. - ISSN 2314-4378 (Vol. 2017, 2017, str. 1-19)
    Type of material - e-article
    Publish date - 2017
    Language - english
    COBISS.SI-ID - 33592793

    Link(s):

    https://www.hindawi.com/journals/ijg/2017/6218353/
    DOI

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