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Organic synthetic environmental endocrine disruptors: structural classes and metabolic fateSchmidt, Jan, farmacevt ; Peterlin-Mašič, LucijaMotnje endokrinega sistema pomenijo tiste spremembe v delovanju endokrinega sistema, ki povzročijo škodljive učinki pri zdravih ljudeh ali njihovih potomcih. Fiziološki endokrini hormoni delujejo v ... zelo nizkih plazemskih koncentracijah, medtem ko se za določene kemijske spojine, poznane kot endokrini motilci (EDCs), prav tako predvideva sprememba endokrine funkcije pri podobno nizkih koncentracijah. V preglednem članku smo se osredotočili predvsem na pregled strukturnih razredov organskih sinteznih okoljskih endokrinih motilcev ter na njihove skupne strukturne elemente, ki jim omogočajo interakcijo z estrogenim signaliziranjem. Endokrini motilci lahko vplivajo na estrogeno signaliziranje neposredno preko interakcije z estrogenimi receptorji (ERs) ali posredno preko transkripcijskih faktorjev kot je receptor za aromatske ogljikovodike (AhR) ali preko modulacije kritičnih encimov, ki sodelujejo pri biosintezi in presnovi estrogenov. Nekateri strukturni elementi hormonskih motilcev predstavljajo tveganje za citotoksično in genotoksično delovanje, predvsem preko bioaktivacije v reaktivne metabolite.Source: Acta chimica slovenica. - ISSN 1318-0207 (no. 4, Vol. 59, 2012, str. 722-738)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 3368561
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Schmidt, Jan, farmacevt | 37786 |
Peterlin-Mašič, Lucija | 19317 |
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