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Profilin 1 as a target for cathepsin X activity in tumor cells [Elektronski vir]Pečar Fonović, Urša ...Cathepsin X has been reported to be a tumor promotion factor in various types of cancer; however, the molecular mechanisms linking its activity with malignant processes are not understood. Here we ... present profilin 1, a known tumor suppressor, as a target for cathepsin X carboxypeptidase activity in prostate cancer PC-3 cells. Profilin 1 co-localizes strongly with cathepsin X intracellularly in the perinuclear area as well as at the plasma membrane. Selective cleavage of C-terminal amino acids was demonstrated on a synthetic octapeptide representing the profilin C-terminal region, and on recombinant profilin 1. Further, intact profilin 1 binds its poly-L-proline ligand clathrin significantly better than it does the truncated one, as shown using cathepsin X specific inhibitor AMS-36 and immunoprecipitation of the profilin 1/clathrin complex. Moreover, the polymerization of actin, which depends also on the binding of poly-L-proline ligands to profilin 1, was promoted by AMS-36 treatment of cells and by siRNA cathepsin X silencing. Our results demonstrate that increased adhesion, migration and invasiveness of tumor cells depend on the inactivation of the tumor suppressive function of profilin 1 by cathepsin X. The latter is thus designated as a target for development of new antitumor strategiesSource: PloS one [Elektronski vir]. - ISSN 1932-6203 (Vol. 8, iss. 1, 2013, str. 1-9, e53918)Type of material - e-article ; adult, seriousPublish date - 2013Language - englishCOBISS.SI-ID - 3375217
Author
Pečar Fonović, Urša |
Jevnikar, Zala |
Rojnik, Matija |
Doljak, Bojan |
Fonović, Marko |
Jamnik, Polona, biotehnologinja |
Kos, Janko, 1959-
Topics
katepsin X |
tumorji |
profilin 1 |
rak prostate |
celice raka
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Pečar Fonović, Urša | 19170 |
Jevnikar, Zala | 26497 |
Rojnik, Matija | 31397 |
Doljak, Bojan | 19785 |
Fonović, Marko | 18801 |
Jamnik, Polona, biotehnologinja | 18511 |
Kos, Janko, 1959- | 04648 |
Source: Personal bibliographies
and: SICRIS
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