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Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedureMašić, Ivana ...Objective: The aim of this study was to investigate the influence of process parameters, binder content and binder addition method on characteristics of the granules obtained by melt granulation (MG) ... in fluidized bed. Methods: Spray-on experiments were performed according to 23 full factorial design. The effect of binder content, molten binder feed rate, and spray air pressure on granule size and size distribution, granule shape, Fowability and drug release rate was investigated. In the in situ experiments, the influence of binder particle size and binder content was evaluated. Solid-state characterization was performed by means of differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy. Results: Size of the granules obtained by spray-on procedure was significantly influenced by binder content and spray air pressure, while the width of particle size distribution was mainly affected by binder feed rate. Spray air pressure showed the most significant influence on granule shape. It was shown that smooth and spherical particles with good flow properties may be obtained by both procedures, spray-on and in situ MG. The results obtained indicated the influence of agglomeration mechanism on granule sphericity, with higher degree of granule sphericity observed when immersion and layering was the dominant mechanism. Paracetamol release from granulates was very rapid, but after compression of the granules into tablets, drug release was considerably slower. Solid-state analysis confirmed that the physical form of the granulate components remained unaffected after the MG process. Conclusion: The results presented indicate that MG in fluidized bed could be a good alternative to conventional granulation techniques.Source: Drug development and industrial pharmacy. - ISSN 0363-9045 (Vol. 40, no. 1, 2014, str. 23-32)Type of material - article, component partPublish date - 2014Language - englishCOBISS.SI-ID - 3377009
Author
Mašić, Ivana |
Ilić, Ilija |
Dreu, Rok |
Ibrić, Svetlana |
Parojčić, Jelena |
Srčič, Stanko
Topics
binder addition procedure |
fluid bed |
growth mechanism |
hot melt |
spray-on |
solid dosage forms
source: Drug development and industrial pharmacy. - ISSN 0363-9045 (Vol. 40, no. 1, 2014, str. 23-32)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Mašić, Ivana | |
Ilić, Ilija | 28446 |
Dreu, Rok | 21455 |
Ibrić, Svetlana | |
Parojčić, Jelena | |
Srčič, Stanko | 09031 |
Source: Personal bibliographies
and: SICRIS
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